ID W5KGH9_ASTMX Unreviewed; 973 AA.
AC W5KGH9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006691.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006691.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KGH9; -.
DR STRING; 7994.ENSAMXP00000006691; -.
DR Ensembl; ENSAMXT00000006691.2; ENSAMXP00000006691.2; ENSAMXG00000006522.2.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT01070000253760; -.
DR HOGENOM; CLU_002274_4_5_1; -.
DR InParanoid; W5KGH9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006522; Expressed in intestine and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF02758; PYRIN; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM01289; PYRIN; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 1..83
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 178..313
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 773..973
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 973 AA; 110530 MW; D84F9EB53032A692 CRC64;
MANAEDVLLE ALQDLESKEL KSFTRHLTKG VKGFDRIRRG LLENAGREEI VDKMVERYKI
SGAVKITRTI LKKIHKNRLA EELDPDYPAA YPRPDYPLKD TLKLNYERVI ESSQTGHQEF
LEDIYTDLVI VQNKSGGVIN EHEVMQIEMS PNKAGSEEEC IKCCDIFKVQ PGTGRRNRKV
MTMGIAGVGK TVSVNKFILD WAEGKENQDI QYIFPLPFRE LNLKKETKFS LIGLLNNCFF
SSKPALKSLP EEDGKVLFIF DGLDEYRYPL EFKDGKEVKD VNEKSTVGSL ITNLINRNLL
SFSLVWVTCR PAAAHLIPQK YINLVTEVRG FNDEQKKEYF TKYCKTEDVA EKISSHIKKL
KSLHIMCQIP VFCWISATVL QPLMDKESEK NIPTTLTEMY MSFLLQQKNL MKEKYSQKTD
PERIILKLGK LAFCNLESGE LNFYEDNLKE CGIDVTDGTV FSGMNIFSFV HLSVQESLAA
VYVHHSHCNK KKNVFKKKVL NKLLWINKKI TDLHKSAVDR ALQSENGHLD LFLRFLLGLS
VEDSQKVLTE LLPNLKIKAE SVSNTAIYIK EKLKEEMHSE RSLNLLHCLS ELKDNSLTAE
IQNFLNSGTL SKQELSSTQW SALIFVLMMS EETQKKFELK KYRASEEGLR RLLPVVKNTQ
RALLDSCDLG VKSCESLKSV LELENSSLIE LDLSNNDLQD SGVELLSAGL KSSHCKLQTL
RLSGCMITEK GCSSLASALS SNPSHLKALD LTYNHPGESG EKLLSARLED PHCSLETLRY
EEKVRFVQNG CYFILDLNTV NPGLSLSEEN RRVERREELQ SYPDHPERFT GWCQQVLSRE
RVTGRCYWEA EWSGWGGAVV ALSYKTISRK GGGSDCRFGE NINSWSLICS DNRYSVEHNK
NRTDLPPPPS GCRRVGVYVD CPAGTLSFYS VSTDTHSHTL THLHTFYTTF TQPLYAGIGV
YYYGSSVTLC KIE
//
