ID W5KGZ4_ASTMX Unreviewed; 733 AA.
AC W5KGZ4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Semaphorin 3C {ECO:0000313|Ensembl:ENSAMXP00000006856.2};
GN Name=SEMA3C {ECO:0000313|Ensembl:ENSAMXP00000006856.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006856.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006856.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; W5KGZ4; -.
DR Ensembl; ENSAMXT00000006855.2; ENSAMXP00000006856.2; ENSAMXG00000006459.2.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159379; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006459; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11251; Sema_3C; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF25; SEMAPHORIN-3C; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 21..506
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 585..650
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 733 AA; 82882 MW; DDE61B40067170CC CRC64;
MLLCIMNCDY KSLIAVFITC YTSIPRNSVP LQTTQAFEFY TLSEKAMDYR ILFMDEDQDR
MYVGCKDHVL SMDINNITQG TLKIFWPASN TKIEECQMAG KDPTHGCGNF LRVIQPYNRT
HLFICGSGAY SPVCAYINRG RRPEEKVFNI ASRGESGKGR CSFSPRVNTV SVMLNQELFS
GMYIDFMGTD AAIFRSLTSR NAVRTDQHNS KWLSEPVFID AHLIPDGSDP NDAKLYFFFR
ERLTDNSGNT KNIHTMVARV CPNDTGGQRS LVNKWTTFLK ARMVCSVLEE DGTETHFDEL
ESVFLLETDN PKGLLLFGIF TSTSSVFKGS AVCVYNMADI LTVFNGPFAH REGPNFQWVA
FQGRIPYPRP GTCPGGAFTP HIRSTKEFPD DVVTFMRNHP LMFNPIYPVG RRPLLVRTHA
EYKYTSIVVD QVAAADGLYR VLFLGTDKGT VQKVVVLPTN RSLGDDLILE ELEVFKNQAP
ITNLRISSKK QQLYVSSEYG VSQVSLHRCN AYGTACADCC LARDPYCAWD GLSCSRFYPT
GKRRSRRQDI MHGNPLTQCR GFNLKAYRNA VEMSQYGIRN NTTFLECIPK SPQASVRWLI
QRDNDRRKEV KLSDRVVATD HGLLIRSVQS SDQGLYYCLA TENGFKRTLA KIRLRVLGEA
VVSALSDKQR SSWGWGLSPK ALASAFSPAE TLAMQQYCKE RKQLQTFQGP LRGDLAKLKP
LLDHNKSRNR RNH
//
