ID W5KH30_ASTMX Unreviewed; 957 AA.
AC W5KH30;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Seizure related 6 homolog a {ECO:0000313|Ensembl:ENSAMXP00000006892.2};
GN Name=SEZ6 {ECO:0000313|Ensembl:ENSAMXP00000006892.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006892.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006892.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KH30; -.
DR STRING; 7994.ENSAMXP00000006892; -.
DR Ensembl; ENSAMXT00000006892.2; ENSAMXP00000006892.2; ENSAMXG00000006718.2.
DR eggNOG; ENOG502QV56; Eukaryota.
DR GeneTree; ENSGT00940000156995; -.
DR HOGENOM; CLU_011474_2_0_1; -.
DR InParanoid; W5KH30; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006718; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF1; SEIZURE PROTEIN 6 HOMOLOG; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..957
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017201487"
FT TRANSMEM 891..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 355..414
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 416..527
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 509..573
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 575..686
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 690..749
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 751..814
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 818..879
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 416..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 720..747
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 957 AA; 104461 MW; 3ABF037C41A5E847 CRC64;
IEWTGKSLKI ILIINELFFF SLSPPGDGTG LSERGGESES ERELNPYTSK HDFHELHEVT
TAPTSSFLDH RPNLRGLLLH EALLTKDFQG DQQFFQQDGG PAARPTAPSH YPQPGDSSTR
VVPHEDAPAF SDIATTAITT ASPTVPSRLV PTPHKRPSKG RGRTTDKLEV TSQSLTTPVV
PASTQPSSEQ QPAEAPTKEH PASKETQRPA GKSSEGNITE RDEETVTSTI HTTTIISTMR
TEGQCSMNFT DAEGYIEMPP RTEDSHDSTV DCTYLITVYL GYGIEIQVLN VTLAEGEKVV
LEDLGGLQPS ILANESVLSR GLVVRSSSNQ ISIHFSSKKH QAPSSLLLRY RAFVLSCAFP
QTPANGEVSV SSLHAGGEAY FFCLTGYQLQ GPSSLTCRNA TMPYWSGKEP KCLAACGGMV
KNATLGRIVS PGFPGNYSNN LTCHWVLQAP EGHRLHVHFE KVALAEDDDR LLIKNGNNID
SPPVYDSYEV EYLPNEGVVS TGRYLFVEFT TDETGTFMSF ILLNISSDLS YGPGTVVEFS
CEPGYTLEQG SVTIECVDPE NPQWNETEPA CRAVCSGEIT DSAGVVLSPN WPEAYDKGQD
CIWGIHVEED KRIMLDIQVL NLGKNDVLTF YDGDDLTANI LGQYSGTLPR FKLYTSMADV
TIQFQSDPAT NIYGYNNGFV VHFFEVARND TCSELPEISN GWKSTSHPDL IHGTVVTYQC
YPGFQVVGSE ILMCQWDLTW SGDVPACEKV MVCQDPGLVE HGRRVVAGSR FTVGSSVQYA
CNKGYSLSGP GVLTCYSRDT ADPKWSERLP KCVPERYEPC SNPGAPSTAI QSSEKAFFQA
GDTLTFSCRP GYQLLGEATI RCLPGHPSQW SGEPPACRVV SSETGAEGTK IAIAVMVPVA
VVLLAVLGVY LYFSKVQGKT LHLPSSSLPP YDNMTEESAF DNPIYETGET RQYEVSI
//
