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Database: UniProt
Entry: W5KHY9_ASTMX
LinkDB: W5KHY9_ASTMX
Original site: W5KHY9_ASTMX 
ID   W5KHY9_ASTMX            Unreviewed;      2706 AA.
AC   W5KHY9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 1b {ECO:0000313|Ensembl:ENSAMXP00000007201};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007201, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000007201, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000007201};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000007201}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000007201};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000007201}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   Ensembl; ENSAMXT00000007201; ENSAMXP00000007201; ENSAMXG00000006873.
DR   GeneTree; ENSGT00940000155071; -.
DR   OMA; PRHAPYK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2241   2263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2275   2294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2362   2387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2407   2429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2527   2550       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED     1597   1617       {ECO:0000256|SAM:Coils}.
FT   COILED     2637   2685       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2706 AA;  308347 MW;  B66CE8F95B5CCCCF CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDTGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGG NSTTDTVLLN KLHHAADLEK KQNESENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDSAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASTHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK EVILKGGDVV
     RLFHAEQEKF LTCDDHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVNP DYEEESHESR SSLDSEHEAL RARLRTPNEK VMYTLVSVPD
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNNPIDKEE EKPVMLRIGT
     SAIKEDKEAF AIVPVPPAEV RDLDFANDAS KVLASIAGKL EKGTITQNER RFVTKLLEDL
     VFFVVDIPNS GQDVLEIMVN KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFRF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICNAVLDPA
     NADILIETKL VLSRFEIEAV NVGEPPVEAE EDEEEVWLFW KDSTKEIRSK SIRELAQDAK
     EGQKEDQEVV SYYRYQLNLF ARMCLDRQYL AINKISGQLD VDLILRCMSD EDLPYDLRAS
     FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSKIAIDDYD NDGTTRDEIK ERFALTMDFV
     ENYLRDVVCQ NVPFSDKEKN KLTFEVVNLA RNLIYFGFYS FSDLLRLTKI LLAILDCVHV
     STIYPINKME KDDENKGSNV MRSIHGVGEL MTQVVLRGGG FLPTTPTAPP DGEVGKTQTE
     PEKEDILVMD TKLKIIEILQ VTGKLWTLGT VLSYGLISCL LCIFKREFDE TNTQTDSLIN
     SNANANSEWS IAKSLDFENI EEQAEGIFGA SEENTPLDLD DHGGRTFLRV LLHLTMHDYP
     PLVSGALHLL FRHFSQRQEV LMAFKQVQLL VTSQDVDNYK QIKSDLDQLR SIVEKSELWV
     YKRQGDDALD GGDGPAESDH KKKVHSKKPE STSSYNYRVV KEILVRLSRL CVQEGASGKK
     SKKQQQRLLR NMGAHSVVLE LLQIPYEKGE DVRMQEIMKL AHEFLQNFCA GNQQNQALLH
     KHINLFLNPG ILEAITMQHI FMNNFQLCSE INERVVQHFV HCIETHGRHV QYLKFLQTIV
     KAENKFIKKC QDIVMAELVN AGEDVLVFYN DRASFQTLVQ MMRSERDRMD ENSPLMYHIH
     LVELLAVCTE GKNVYTEIKC NSLLPLDDIV RVVTHEDCIP EVKIAYIDFL NHCYVDTEVE
     MKEIYTSNHM WKLFENFLVD ICRVCNNTSD RKHADATLER YVTETVMSIV TTFFSSPFSD
     QSTSLQTRQP VFVQLLQGVF RVYHCNWLVP TQKASVESCI KVLSDVAKSR AIAIPVDLDS
     QVNNLFVKSN NVVQKTILNW RMSARNASRR DSTLTTSKDY RNIIERLQDI VSALEDRLRP
     LVQAELSVLV DVLHRPELLF PENTDARTKC ESGGFISKLI KHTKQLLEEN EERLCIKVLQ
     TLREMMTKDR GYGEKGEALR QILVNRYYGN FKPGGRRDSL TSFSNGPLGA GGQSKAPAAA
     AGGSGGSRGE MSLAEVQCHL DREGASDLVI DLIMNATSDR IFQESILLAI ALLEGGNTVI
     QRSFFIRLTR DNKSEKFFKV FYERMKLAQQ EIKATVTVNT SDLGSKRKDE DTNDKEAPTK
     KKVKDVAVVT DEVREQLLEA STVTKKAFAA YRREVDSDEH LSGGEVQTST AEKIQDENEM
     SVTITIMQPI LRLMQLLCEN HNRELQNFLR CQNNKNNYNL VCETLQFLDC ICGSTTGGLG
     LLGLYINEKN VALINQTVES LTEYCQGPCH ENQNCIATHE CNGIDIIIAL ILNDINPLGK
     KRMDLVLELK NNASKLLLAI MESRHDSENA ERILYNMRPK ELVEVIKKAY MQGEIEVEHT
     DEEGEGEEEH AASPRNVGHN IYILAHQLAR HNKELQAMLK AAGSYGEGDE ALEFYAKHTA
     QIEIVRLDRT MEQIVFPVPN ICEFLTQESK LRVYYTTERD EQGSKINDFF LRSEDLFNEM
     NWQKKLRAQP ILYWCSRNMS FWSSISFNLA VLMNLLVAFF YPLGGIRGGT LDPHLSALLW
     VAMLVSLAIV IVLPQPHGIR ALIASTILRL IFSVGLEPTL FLLGAFNVCN KVIFLMSFVG
     NRGTFTRGYK AMIMDVEFLY HLLYLIICSL GVFVHVFFYS LLLFDLIYRE ETLLNVIKSV
     TRNGRSIVLT AVLALILVYL FSIVGYIFFK DDFILAVDRI PNKTMMSEFL TGGVCRKEGG
     GENCSSEVTT ETVAMVVEDK ERTCDSLLMC IVTVLSHGLR SGGGVGDVLR KPSKEEPLFA
     ARVIYDLLFF FMVIIIVLNL IFGVIIDTFA DLRSEKQKKE EVLKTTCFIC GLERDKFDNK
     TVTFEEHIKV EHNMWHYLFF IVLIKVKDST EYTGPESYVA EMIREHNLDW FPRMRAMSLV
     SSDAEGEQNE IRSLQEKLES TMKLVSNLSG QLTELKEQMT EQRKQKQRIG LLGHPQHMNV
     NPQQPA
//
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