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Database: UniProt
Entry: W5KIH7_ASTMX
LinkDB: W5KIH7_ASTMX
Original site: W5KIH7_ASTMX 
ID   W5KIH7_ASTMX            Unreviewed;       636 AA.
AC   W5KIH7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 30.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007389, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000007389, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000007389};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000007389}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000007389};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000007389}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   Ensembl; ENSAMXT00000007389; ENSAMXP00000007389; ENSAMXG00000007197.
DR   GeneTree; ENSGT00390000006586; -.
DR   OMA; GWGKGIV; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN       20    336       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      525    593       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    168    168       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    248    248       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   636 AA;  70935 MW;  F5ED17027D797BC0 CRC64;
     RKSFSDCTAP SFSVDYKRNS FLKDGERFRY ISGSIHYSRI PRVYWKDRLL KMYMAGLNAI
     QTYIPWNFHE PTPGSYDFSG DRDLEHFLQL CQDLGLVVIL RPGPYICAEW DMGGLPTWLL
     KKKDIVLRSS DPAYIAAVDK WMGKLLPMIK PYLYQNGGPI ITVQVENEYG SYFACDFDYL
     RHLIRLYRSY LGDEVVLFTT DGARVSYLKC GSIQGAYATV DFGAGGNVTA AFEAQRHAEP
     HGPLVNSEFY TGWLDHWGEP HAVVSTAILV KSLNEILEVG ANVNLYMFIG GTNFGYWNGA
     NTPYAPQPTS YDYDAPLTEA GDLTQKYFAI RDVIKKYRKI PDGMVPPSTP KYAYGQVPMK
     KLRTVAESLD ILSFSGPVKS TYPLTFTDMK QAFGFMQYQT VLPVDCINPT PLSSPLNGVR
     DRAYVSVDGV VAGILERDKA ITINITGKAG SRLDILVENL GRVNFGKDIN DFKVSLTSVL
     ANWTVYSLSI DEAVKGGLLL DTVSLRPPKT TTPKTPPTKL SPPAFYAGSF SIPDDIPDLP
     QDTYIQFPDW RKGQVWINGF NLGRYWPSRG PQITLFVPAY LLSTSAPNNI TVLELEASPC
     SSGPCAVEFT NTPNINATTR FTTPFIRDPL NLQGLL
//
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