ID W5KJ75_ASTMX Unreviewed; 1113 AA.
AC W5KJ75;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=PTPRF interacting protein alpha 4 {ECO:0000313|Ensembl:ENSAMXP00000007637.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007637.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007637.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; W5KJ75; -.
DR Ensembl; ENSAMXT00000007637.2; ENSAMXP00000007637.2; ENSAMXG00000007380.2.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT01050000244900; -.
DR HOGENOM; CLU_006923_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007380; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF5; LIPRIN-ALPHA-4; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 763..829
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 876..933
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 957..1026
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 119..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3..44
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 387..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 537..571
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 489..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 126485 MW; 880B172318CF07ED CRC64;
MEFATLTKEL NTCREQLLEK EEEISELKAE RNNTRLLLEH LECLVSRHER SLRMTVVKRQ
APPPSGVSSE VEVLKALKSL FEHHKALDEK VRERLRVALE RVTTLEGQLA TTTQELSMVR
QGKSEGNSVD RMDGSKPTWK RLPNGSIDVH DEASRCLELQ EMLDKANKEL ATSRERSNTL
NSRVAELEGE LAGVRKELLK SEELSTKHQR DIREAMAQKE DMEERITTLE KRYLAAQRET
TSIHDLNDKL ENELATKDSL HRQSEEKVRH LQELLELAEQ RLQQTMRKAE TLPEVEAELA
QRVAALTKAE ERHGNIEERL RQLESQLEEK NQELGRARQR EKMNEEHNRR LSDTVDRLLT
ESNERLQLHL KERMAALEDK NALIHDLENS QKQLEEFHHT KERLIGEIEK LRAEIDHLKR
RSGAFGDGTH PRSHVGSATD LRYSVVEGQG DHYSSTGVIR RSQKGRLVAL RDEPTKILPM
VEQDWDRSQP PSLRASRSHL MGSDTELSDL DDEDRETIFS SADMLSPSGH SDAQTLALML
QEQLDAINEE IRMIQVERES AELRADEIES RVNSGSMDGL NVTLRPRSTI PTSVTALSLA
SSSPPVSGRS TPKMASRSAA HELGIMTLPS DLRKHRRKVA SPVEAREDKA TIKCEMSPPS
SPRSLRLDQM NFAQLTGSLE DGRGGNKKKG IKSSIGRLFG KKDKGQPMSK DGQMTPPIIP
ADFEMSIGDT MTLGKQAERD RRMKKKHELL EDARRKGLPF AQWDGPTVVS WLELWVGMPA
WYVAACRANV KSGAIMSALS DTEIQREIGI SNPLHRLKLR LAIQEMVSLT SPSAPLTSRT
SSGNVWVTHE EMENMAASTK ATLAYGDMNH EWIGNEWLPS LGLPQYRSYF MECLVDARML
DHLTKKDLRT HLKMVDSFHR ASLQYGIMCL KRLNYDRKEL DRRRDDCQND IKDTLVWTND
HVMHWVQTIG LKEYSNNLLE SGVHGALVAL DETFDFSSLA LILQIPMQNT QARQILEREF
NNLLALGTDR RLEEGDDKSF RRSPSWRKRF RPREGQGLGM MPGSMETLPA GFRLTTMSIP
ASMAVVPKRQ LQPEAGPPPP QRIDPSVVRT YSC
//
