ID W5KJ88_ASTMX Unreviewed; 2615 AA.
AC W5KJ88;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Teneurin-2-like {ECO:0000313|Ensembl:ENSAMXP00000007650.2};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSAMXP00000007650.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007650.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007650.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSAMXT00000007650.2; ENSAMXP00000007650.2; ENSAMXG00000007446.2.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007446; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 2.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..216
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 509..541
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 543..576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 649..684
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 16..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 531..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 566..575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 653..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 674..683
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2615 AA; 288929 MW; 9ED5B33106C1EC20 CRC64;
MCCVCLCVCS SGRPLPPTPS SSLLPPTPPP PSGPHNPAAP SIRECQMPLL DSGSSHAMLD
PPPDDEFSPN SYLLRAQPPI AGPSSHHSQL APRPPLPPPH NHHQSSANSL NRSAHASRRN
PQSHTPTSAP VDGPSTPESV QLQDSWALNS SVPLETRHFL FKTPSGSTPL FSSSSPGYPL
TGGTVYSPPP RLLPRNTFSR SSFKLKKPSK YCSWKCAAVS AIAAAVLLAV LLSYFIALNL
LGLNWRLKPT DGHLVTTSLS TGIPGTGEVA AVPSGGRGPW LLRNSSINSG ELEVGRRVSQ
EVPPGVFWRS LLHLRQPHFL KFNISLGKDA LFGVYMRKGL PPSHAQYDYM ERLDGKEKWS
VVESPRERRS IQTVVQNEAI FVQYLDPGTW HLAFYNDGKE KEPVSFSTVA LDSVQECPQN
CHGNGECTSG VCHCFPGFHG MDCSKAACPV LCSGNGQYSK GVCMCYSGWK GLECDVPVSQ
CIDPECGGHG TCSQGTCTCA AGYRGDSCEE VDCLDPMCSG HGTCLQGQCH CKLGWTGPLC
DLPRAQCPDQ CHGHGVYSAD TGLCSCDPNW MGPDCSTEVC SADCGSHGVC VGGVCHCEEG
WAGAGCDQRL CNPQCVKHGT CRDGKCQCEQ GWNGEHCTIG KYTHTHTSDH NGCPGLCNGN
GQCIMGQNSW HCECHTGWRG PGCSVAMEIS CNDNKDNEGD GLVDCMDPDC CTQTSCLTNP
LCRGSRDPLQ VIQQSQSAGQ KVSSFYDRVK VLVGRDSTHI IPGSNPFNTS LASLIRGQVL
TSDGTPLVGV NVSFVKYPHY GYTMTRQDGT FDLVANGGSS LTLRFERAPF LSQERTVWLP
WNRFYAMDTL VLKTEENTIP GCDLSGFVRP DPVVVPSPLS SFFSSNPTEK HIIPETQVLH
EQVEIPGTSL NLCYLSSRAS GYHALLKVTM TPALVPLSLA KVHLMVAVEG HLFQKWFHAS
PNLAYTYIWD KTDAYRQRVY GLSEAVVSVG YEYETCPSQI LWEKRTAVLQ GYELSPSNLG
GWSLDKHHTL NIRHGILHKG SGENVFISQQ QPPVISSIMG NGRRRSISCP SCSGLAEGNK
LLAPVALACD GEGNLYVGDL NFVRRVYPSL NTTAILELRN KDLRHSNSPS HKYYLAVDPV
SGALLLSDTN SRQIYRVRSL SGGHPLLENA QVVAGTGEQC VPFDEARCGD GGKAVEATLM
SPRGIAVDKN GLMYFVDATM IRKVDQNGII STLIKTNDLT AVRPLSCDSS MDVSQVRLEW
PTDLAVNPMD NSLYVLENNV VLRITENHQV SIVAGRPMHC QVPGIDYSLS KLAIHSALES
ATAISISHTG VLYIAETDEK RINRVRQVSA SGEISLLAGA ASECDCKNDV NCNCFSGDEG
YAADANLNSP ASLAVSPDGT LYIADLNNIR VRGVHRNQPN STSSAAAGRY EVGSSLEQEL
YLFSEDGLHR QTVSLVTGLP LYNFSYGMDG ELASVTDNSN NTLKIRREAG GSVRLVLLPE
NQVVTLGMDA AGSLRSVSAL NQEVAVLSYA GNTELLASKS DETGWTNFYE YDSEGRLTNV
SYPTGMVTSL HREMEQSINI DMESSNRDDD VTVITNLSSV EASYTVVQDQ VRNSYQMYYN
GTLRVSYANG MGISFHTEPH ILAGSVSPTI GRRNISLPTD SGLNSIEWRM RKELTKGKVT
VFGRKLRAHG RNLLSIDYDR TTRTEKVYDD HRKFTLRIIY DAQGRPATWL PSSSLALVNV
SYSPTGCLVG LQRGSMSEKS EFDSFGRILS RTFVDGKVWS FSYLDKSMVL LLQQSQKQYV
FEFDTSGRIT AVTMPSMARH TMSTHVSVGY IRNTYNPPES NATVIHDFTE DGRPRATFYL
GTGRRMLYKY GKLAKLSEVL YDSTAVTFGY DETAGVLKMV NLQSGGFSCT IRYRKLGPLV
DKQMYRFSEE GMVNARFDYT YHDNSFRVAS VKPVIGETPL PVDLYRYDEI SGKVEHFGKF
GIIYYDINQI ITTAVMTLSK HFDAHGRIKE VQYEIFRSLM YWMTVQYDSM GRVIKRELKI
GPYANTTQYR YEYDGDGQLV GVKVNDWSTW RYSYDLNGNL HLLNPGNSAR LLPLRYDLRD
RITRLGDVQY KLDEDGVLCQ RGSDVFEYNS KGLLERAYSR TGEGWSVRYR YDGLGRRVSR
RTISGEHQQY FYADLNYPAR VTHVYNHTRA EITSFYYDLQ GHLFAMEVSS GEEYYIASDN
TGTPLAVFSS NGQMVKQLQY TAYGEIYHDS NPDFQLALGF HGGLYDPLTK LVHFAQRDYD
VLAGRWTSPD HTMWAKMGKE PAPFNLYMFK NNNPLSDMID VKNYVTDVKS WLVMFGFQLS
NIIPGFPRHP LYFVDPPYEL LSSQDCDNAQ LFTGVQHSVE RHNQAFMALE GRLLNKQRRA
KHDKPGYWFG TSTPIVGKGM MLAIRDGHVL TSVSSAASED SRKIAQILSN TIYLEGTHYT
IDGRDWHFFV KLGLADGDLL ALGFSSGRKT LENGVNVTVS GRSRRGVTME IHTATLAFSI
RYGLTPEVLE KERARVLEQA HQRAMARAWA REQQQVQEGR DGGRAWTESE KQQLLAVGKV
PAYEGYYVLP VEQYPELADS STNVQFLKQN EMGKR
//
