ID W5KJD7_ASTMX Unreviewed; 1336 AA.
AC W5KJD7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=MAGI family member, X-linked a {ECO:0000313|Ensembl:ENSAMXP00000007699.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007699.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007699.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR Ensembl; ENSAMXT00000007699.2; ENSAMXP00000007699.2; ENSAMXG00000007490.2.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000164755; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR InParanoid; W5KJD7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007490; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.42.10; -; 5.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF41; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 5.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 26..94
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 102..176
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 267..299
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 625..690
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 816..903
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 930..1012
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 210..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..438
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 143177 MW; 52B09F0EE3CEAF74 CRC64;
MSKATVKKLH WRSKVQESFV PLGGASGELG VAIGGGADYG EFPFVTAAPG GGATVGDIIL
EIGGTPVLGM TLGDVRGVLN SCPHPIRIKT VSPGSTLCKD LRLYLSKCFT PGSMDSQLQQ
VIRENLYLRA VPTTRQPRDG EISGVDYNFV SIEEFFSLEE SGALLESGKF KNYYGTPRPV
HIGPDSPPIT YQEHRNLLRN FRTRSKSLSN LEKAVEEGDN SEEDSGLSGS AGAGSAPPTT
IVSPNQTWDS GGPRDGGVTL ENGARGGALP ENWEMAFSDS GEPYYIHNSK TTSWLDPRTH
SKEIVSKTEP PFTDQPSDLK GYSIHTRLSK GPRGFGFNIV GGSRPREFLQ VYSVTPGGPP
ALNTDILVYI NDLCVLGMSH KEVVEMLKGV PMGHSVDVVL RRGYPMLYNP DGCPKTSLSS
PADPPPGSAQ PPPPPEGLAN LNRAVSLHNG FYPRLQKEAL DANGNAAAPP SYSMPNGNIA
GGAIGLVGVA SKLPPPRTER LSSSHSDTEV SSTVTRASLI RTYNNNTLPA PSLAHQSSKS
SESDLSTGTL PLPQPEVGSA AAPPGAPSSQ RPLMPQTSLV ISPPTELPPC GFNGCPANNP
PRPAPGSLGS PSGSSGAGAG GELVPVALGR SEGGGMGFSV TAGGQGGQLA LVKRVWDRRQ
CPSLQPGDAI IKINGADVQS LSFAQQVQRV LQEHTKQGEV VLLVYRGSAV SPASSNYYKT
VPPPQGPPDL TSPSSDGPTT SQSTLSPLSP SGELPPLVQS TSFLDSVPVT LTMEPRDWMG
VDDVPGQGPR TSDSALGAVS KNPADGRGAP PPKTLEVELR RRPGEGFGFV IASQDVKNGS
SIFSHRFVTV RRGSPAARSG QIQHGDQLEA VEGRSVVTLP HRDLAQILRR AGNTLRLTII
PRSNTYTDFD PESRLRKGQR SKQKDPRYYS VDLERGPTGF GFSLRGGSEY NMGLYVLGLM
EGGPASRSQK IQVSDQLVEI NGDSTSGMTH SQAVEQIRKG GHRIHLVLKK GNGYVPDYHE
GGAASPSSLC SEEPGVASVA FSLTKSIQKD DDDRGADRRE WRRKGGSSRG GGEEGREERR
GAPDSDRGGG DSASVTLSSR SGKRKEIKKQ TQSQSLTKKA QKGGETEGEE EQVQRGERGE
ERRSRSLGDR RSKGRSRGES VERLLEGREK RESFSTKEEE GDRTESRRER KGRDEKRERR
KERDNRVFDV DQPESRGRNE KRERRKEGKR KNGYNTAPEG LVIEVPQKAP FSFLMPLDDN
SDLSDANSTF SFSEVSVSAA SVSLAGTEWP QNPSELQEDP GSPGLSPGPW LVPTPYTLSQ
VLDGNRLSRR EGGLWF
//