ID W5KJX2_ASTMX Unreviewed; 747 AA.
AC W5KJX2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007884.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007884.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; W5KJX2; -.
DR STRING; 7994.ENSAMXP00000007884; -.
DR Ensembl; ENSAMXT00000007884.2; ENSAMXP00000007884.2; ENSAMXG00000007666.2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_5_1; -.
DR InParanoid; W5KJX2; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007666; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 106..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 139..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 187..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 384..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 479..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 534..734
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 581..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 81751 MW; 683FF46EE3A2195D CRC64;
MEHVTADEEP PAAAAAAAAL EYRVQRNVFD EEHLSSQLLH KKERTPKSIG QRLAESCRCS
SERAKSAIFS FLPILSWLPS YPVKEYLFGD IVSGLSTGVM QLPQGLAYAM LAAVPPVYGL
YSSFYPVLLY TLFGTSRHIS MGTFAVISLM IGGVAVREAP DSMFPLNGTN VTGLVDFEAR
DARRVQVAVA LTTLVGLIQL FLGVLRFGFV AIYLAEPLVR GFTTAAAIHV FVSQLKYLFG
VKTKRFSGPL SVLYSLIAVF KDITSTNVTT LIVGLVCIVF LYSVKDVNER FKKKLPIPIP
GEIIVVIVST GVSYGMALFE NYQVDIVGSI PVGLLPPVIP DFTLFPNLVA DAVAIAVVSF
SMGISLAKIF ALKYGYSVDG NQEMIALGLC NFASSFFQTF VITSSMSRSL VQESTGGKTQ
IAGLLGSLLV LLVIVAIGFM FEPLPQTVLA AVIMVNLLGM FKQVRDIPAL WRTSKIELAV
WLVAFVASVL LGLDFGLLVA VGFAILTVIY RTQRPKSVIL GQIPNTGLYY DIDEYEEASE
CSGVKIFHSN SSIYFANSDQ YVNHLKDKTG IDPTRLLAER KSQQKHAKTK KEEKKNLKDS
SSPQKRNAVA KLDMELGVAH EVLDESEKQV ELHGNGQLPE AQSEICDSEK VLFLQPLCPV
HSIILDFTPV NFMDSVGIKA IKAVIKEYAA VDVRVVLAGC NRTLLSDLRK MQFFSGPVTT
DIIFPTIHDA VLYCQHKRAL LLSPEVQ
//