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Database: UniProt
Entry: W5KJX2_ASTMX
LinkDB: W5KJX2_ASTMX
Original site: W5KJX2_ASTMX 
ID   W5KJX2_ASTMX            Unreviewed;       747 AA.
AC   W5KJX2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE   AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007884.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000007884.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; W5KJX2; -.
DR   STRING; 7994.ENSAMXP00000007884; -.
DR   Ensembl; ENSAMXT00000007884.2; ENSAMXP00000007884.2; ENSAMXG00000007666.2.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_5_1; -.
DR   InParanoid; W5KJX2; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000007666; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR   GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        106..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        139..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        187..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        269..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        384..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        479..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          534..734
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          581..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..601
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  81751 MW;  683FF46EE3A2195D CRC64;
     MEHVTADEEP PAAAAAAAAL EYRVQRNVFD EEHLSSQLLH KKERTPKSIG QRLAESCRCS
     SERAKSAIFS FLPILSWLPS YPVKEYLFGD IVSGLSTGVM QLPQGLAYAM LAAVPPVYGL
     YSSFYPVLLY TLFGTSRHIS MGTFAVISLM IGGVAVREAP DSMFPLNGTN VTGLVDFEAR
     DARRVQVAVA LTTLVGLIQL FLGVLRFGFV AIYLAEPLVR GFTTAAAIHV FVSQLKYLFG
     VKTKRFSGPL SVLYSLIAVF KDITSTNVTT LIVGLVCIVF LYSVKDVNER FKKKLPIPIP
     GEIIVVIVST GVSYGMALFE NYQVDIVGSI PVGLLPPVIP DFTLFPNLVA DAVAIAVVSF
     SMGISLAKIF ALKYGYSVDG NQEMIALGLC NFASSFFQTF VITSSMSRSL VQESTGGKTQ
     IAGLLGSLLV LLVIVAIGFM FEPLPQTVLA AVIMVNLLGM FKQVRDIPAL WRTSKIELAV
     WLVAFVASVL LGLDFGLLVA VGFAILTVIY RTQRPKSVIL GQIPNTGLYY DIDEYEEASE
     CSGVKIFHSN SSIYFANSDQ YVNHLKDKTG IDPTRLLAER KSQQKHAKTK KEEKKNLKDS
     SSPQKRNAVA KLDMELGVAH EVLDESEKQV ELHGNGQLPE AQSEICDSEK VLFLQPLCPV
     HSIILDFTPV NFMDSVGIKA IKAVIKEYAA VDVRVVLAGC NRTLLSDLRK MQFFSGPVTT
     DIIFPTIHDA VLYCQHKRAL LLSPEVQ
//
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