ID W5KK78_ASTMX Unreviewed; 804 AA.
AC W5KK78;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Rho GTPase activating protein 17 {ECO:0000313|Ensembl:ENSAMXP00000007990.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007990.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KK78; -.
DR STRING; 7994.ENSAMXP00000007990; -.
DR Ensembl; ENSAMXT00000007990.2; ENSAMXP00000007990.2; ENSAMXG00000007770.2.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00940000156201; -.
DR HOGENOM; CLU_013806_0_0_1; -.
DR InParanoid; W5KK78; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007770; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04386; RhoGAP_nadrin; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF3; RHO GTPASE-ACTIVATING PROTEIN 17; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 14..246
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 255..445
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 466..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 169..196
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 558..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..711
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..751
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 88073 MW; 4545D983DE5506E4 CRC64;
MKKQFNRMKQ LANQTVGRAE KTEVLSDDLL QIERRLETVR LISHNVHKKM ISCLQGHVGT
EVDKRHKKMP LSGLSQAMLE GWNQLGEESM IGKIMEVCGE AENKLAYEQS QHEVQLERDI
LDPINQLAEV DIPNILKQRK QLAKLVLDYD SARARYLQAT KAILTATNNP AMSAKADSLK
EEMDEAHNKV EICKDQLAAD MYAFSSKEGE YACYYVVLLE AQAEYHKRSL ASIESLLPSI
RSKQDTWTEK PAFGTALEEH LKRTNREIAL PIEACVMMLL ETGMKEEGLF RIAAGASKLK
KLKAALDCST SQLEEFYSDP HAVAGALKSY LRELPEPLMT FQLYDEWIQA SNISDSDKRL
QALWVICDSL PKANKANLRY LVKFLAKLAQ ESEVNKMTPS NIAIVLGPNL LWAKTEGTLA
EMAAATSVHV VTIIEPIIQH ADWFFPDDVE FNVSGMFALP TAPMHQLSYP GTPEPEPHTI
DRRRPGSQGG LEPESPRRDS PASKQPELAP RRGATLYRKQ HSSPSFQPPL PPVEAGEAPP
QSPVGGSEAG LAGAILAQTQ QPLGQQQSAE DSSSNVAREP ASTPPSLRNG PRGPVGTPTQ
LMVESPFPSS KGPSPHMVRR GTKKQAPAPP KITPNPSPPT AQTPKSVSNP YAPAPSPMAS
TPQPVIIPRR QSNNQIPIQA PNHPPPQPPP QSTPEPDPSP PRTPTPPDTP PHDSLQNTQH
SSFHSGSLPR PRPLPRPRPR PSVPPPPQPV SDDANGVCTS ASRIITDVGL SFKGPGRVLV
PVIAVEQLET TPSDAEHHSE STML
//
