ID   W5KM62_ASTMX            Unreviewed;      1336 AA.
AC   W5KM62;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Tectonin beta-propeller repeat containing 2 {ECO:0000313|Ensembl:ENSAMXP00000008674.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008674.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000008674.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 7994.ENSAMXP00000008674; -.
DR   Ensembl; ENSAMXT00000008674.2; ENSAMXP00000008674.2; ENSAMXG00000008427.2.
DR   eggNOG; KOG3621; Eukaryota.
DR   eggNOG; KOG3669; Eukaryota.
DR   GeneTree; ENSGT00940000157283; -.
DR   HOGENOM; CLU_005841_0_0_1; -.
DR   InParanoid; W5KM62; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000008427; Expressed in muscle tissue and 14 other cell types or tissues.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR23287; RUBY-EYE2-LIKE PROTEIN; 1.
DR   PANTHER; PTHR23287:SF16; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF06462; Hyd_WA; 5.
DR   SMART; SM00706; TECPR; 9.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   REGION          495..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1312..1336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1336 AA;  147997 MW;  D3BB9D3C3B09FFCC CRC64;
     MASHPPSIPL REFCPLYYLL NAIPAKVQKG FRSVLVYLTA LDSNSDFIAV GSSIGMLYLY
     CRRVSQMNKY NLEGKSEAIT VVKLLSCFDD LVAVGTASGR VALFQLVSQL PGRNKQLRRF
     DVVGLHKSTI TALAWSANGM KLFSGDDKGK VVYSAVDLDQ GVCNPVVLLE EPSAVVQLEY
     SQKVLLVSTC QRSLLFYTQE QSLQQLGTKP RKNGKFGACF QPGLCKQSDL LVYAARPGLR
     LWRTDVRGRV QETHVLKPLF NQDVPQFELF PRSGPTGAYR PTERQLGLVS CFLKDGWVLS
     WNEYSVYIVD CTNQVIVGGL ESSGDIVSVS CTENEIFILK GDRDIMRISN CPEGLVSNSD
     LSLRLTSPLS TPTILLPPNG AVETAQPIRT MPIIVERESD PSPVERAEVE DSEEVHEEFS
     QALEALEVGE EMEGQQRVFV DMRSRSSSVT SWESAQGVFT ASTPATEASE LSSSRYSAIT
     QEDFQQELVV KQVKLKKKGK RRRQSGNRVN ERSSWSEGMF SHDGMASDAL ATPLSEPPSD
     RTSLLCSSLD LHSNGSPDQE GSICGETLLT PNLPDLLQRQ EQNENQDQEP GAHLSFPTSL
     PLQEMECQTY AESEAQIAAT PDVDILLECT FSYVQAAEEK SVMEEDAKDD AGLLQQDLHR
     DFDLDLPYDP IRPLACSPEP EHEPSPSSDE EDIYAHGVPS SASVGDGLST LTLQGCASNR
     AEQEEARLLK DQLAESWMGY SGPGCGILSL VVTDRHVWCL DFKGGLYCSG LPNGGLSWQK
     FEENVQQVAL SPSSLLWKVE QKTMTAYACG KVTIKGKRHW YKALDETAFV ALSDDTAWII
     RTSGDLYLQT LSVDRPCARA VKVDCPCPMA QMAARGSVVW ALSEQRALFY REGLSSYCAE
     GEQWKYDKVE NQGLEPICIA LGENNTLWAL DTIGSLWFRT GITTKKPQGE DEHWWQVSIT
     DYVVFEQSGL FQTLIQATQS VATATKAPVE RVAERLRVAF LSQQSQCQPS LVSANNSGVW
     IASGRNDFHV AKGSLVTFWR TIVPRGTASA TKWAFVFSSA VPGKESFLWL GQSRKDLFCI
     WDQDLQMRPL TVQLPPDMEM VQLSACRDAL WGLDNHGRVH IRTLSPSCPT GMHWTPLDLS
     QLRLRLISFS CGSQNVWACD TSGMVHFRVG TQPLNPSMML PAWICIEPPE QPVGVHLVRV
     QTSPNDRMLW ALDSRGNVHV RTGITEEMPV GTAWEHIPLQ ASQLVLSTRT AWVRCHNGEV
     ARRYGISEKN PAGDYWKKVP GLVNWLATPL DELWALTPAG VLTQRLTKTL PHNAGKNHGN
     TGSLSGEELE EEWEVI
//