GenomeNet

Database: UniProt
Entry: W5KMZ7_ASTMX
LinkDB: W5KMZ7_ASTMX
Original site: W5KMZ7_ASTMX 
ID   W5KMZ7_ASTMX            Unreviewed;      4937 AA.
AC   W5KMZ7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSAMXP00000008959};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008959, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008959, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000008959};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000008959};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000008959}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   Ensembl; ENSAMXT00000008959; ENSAMXP00000008959; ENSAMXG00000008578.
DR   GeneTree; ENSGT00940000155288; -.
DR   OMA; SKMSAFC; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4227   4250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4457   4477       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4541   4562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4677   4695       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4759       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4818   4841       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       91    146       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      153    198       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      206    261       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      267    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      332    389       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      950   1146       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1280   1494       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      455    475       {ECO:0000256|SAM:Coils}.
FT   COILED     1801   1821       {ECO:0000256|SAM:Coils}.
FT   COILED     1823   1857       {ECO:0000256|SAM:Coils}.
FT   COILED     2032   2052       {ECO:0000256|SAM:Coils}.
FT   COILED     3602   3629       {ECO:0000256|SAM:Coils}.
FT   COILED     4390   4410       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4937 AA;  559624 MW;  E19C33498904863E CRC64;
     IKKGDGGERS ETTIDQVVLQ CTATILKEQI KLCLSCEGFG NRLCFLETTS NAQNVPPDLA
     ICCFILEQSL SVRALQEMLS HTSESSQGGG HRTLLYGHAI LLRHTHSSMY LSCLTTSRSL
     TDKLAFDVGL QEDSTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYASG
     DLMVDASFMQ TLWNMNPVCS GCELAEGYLT GGYVLRLFHG HMDECLAIPA ADQGADQRRN
     AHYEGGAVCS HARSLWRLEP LRIGWSGSHI KWGQAFRIRH ITTGRYLSLD DEKGLLLVDP
     EKANTKSSAF CFRASKEKTE VTQKRDVEGM GTPEIKYGES MCFVQHVATS LWLTYASVDA
     KSARLGPLKR KAILHQEGHM DDALTVARSQ TMESQAARMI YSTAGLFTQF IKSLDSLSGK
     NKTPGPPQPL PLDAVVLSLQ DLIFYFRPPE EELEHEEKQS KLRSLRNRQN LFQEEVRHNT
     ACAEDRPEMS TSLIRGNRAN CALFCDNLDW LVSKLDRLEA SSGILEVLYC ILIESPEVLN
     IIQENHIKSI IALLDKHGRN HKVLDVLCSL CVCNGVAVRS NQNLITENLL PGRDLLLQTS
     IINYVTSMRP NIFLGTCEGS TQYKKWYYEL IVDHVESFLT PQAGHLRVGW ALTEGYSPYP
     GGGEGWGSNG VGDDLYSYSF DGLHLWSGRV PRQVASPSQH TLATSNLLMS ECIKGAVCFV
     LLCRVRFLLG GRHGDFKFVP PPGYAPCFEA VLPKDRLRIE PIKEYKHDLN GVRNLLGPTQ
     SLSHTAFTPN PVDTVQIVLP PHLERIREKL AENSHELWAV TRIEQGWTYG PFRDDNKKLH
     PCLVDFQGLP DPEKNYNLAM SGETLKTLLA LGCHVGMGDE KAEENLKRTK LPKTYMQSNG
     YKPAPLDLNH VKLTPNQNTL VERLAENGHN VWARDRVRQG WTYSIVQDIV NKRNPRLVPY
     NLLDEKTKKT NRDTVCAAVR TLIGYGYNIE PPDQESSGHG VGDGSGNKIR VFRAERSYAV
     TQGKWYFEFE AVTVGEMRVG WARPSVHADK ELGSDDLAYV FNGFKAQRWH VGSEPFGRQW
     QSGDVVGCMI DLTEQNIMFT LNGEMLISDS GSEMAFKDIE IGEGFIPVCS LGLSQVGRIN
     LGQNVSSLRY FTICGLQEGF EPFAINMKRD ITMWFSKSLP QFVPVPTDHP HFEVSRVDGT
     VDSAPCLKLT HKTFGSQNAN TDLLFFRLSM PIEFHETFKV PAGQTPLTRA LTIPEDEVLE
     VDPNSDYELL KKCATRKEQE EKEKEPSVPK ELPGIKEGEN EKDTTTEKSK KKGFFSKAKK
     AAFIAPSPVV PTVPRLVEDV VPDDRDDVEI ISSTTTYYYS VRVFAGQEPS GVWVGWVTPD
     YHQYDLHFDL SKVRNVTVTV GDDKGNIHES MKRSNCYMVW GGEFSSSQQT RISQEDFVIG
     CLVDLDTGLM TFAANGKEVN TFYQVEPNTK LFPAVFCLPS SQNMLQVELG KLKNIMPISA
     AMFRSDRKNP VPQCPPRLDM QMLTPVIWSR MPNDFLAPDT GRVSEKLGWM VQCTEPLTMM
     ALHIPEENRC IDILELSERM DLMKFHYHTL KLYGSVCALG NNRVSHALCS HVDESQLFYA
     IENTYLPGPI RSGYYDLLIS MHLESAKRNR LMTNREFIVP MTDETRSITL YSDAEKAHAL
     PGVGLTTCLR PKLHFAPTGF VGTNADLYTL SPVIPLQMLK DHALSMLTEA VQDGGQAMRD
     PVGGSVEFHF VPILKLISTL LIMGVFEDED VKHILKLIEP SVFNDSDPPV HEGEEGEQPE
     LRREEGAQER KEEKHREQED ELVDEGVAEE EEEEEELEEE EEEEEEQTER EEEGQDALAE
     KTDREKETDE EAGLEAEPAV GKEEPKEHED VGEGLLHMKL PESVKLQMCT LLQYFCDCEL
     RHRVEAIVAF SDRFVNQVQT NQRQRYNELM QAFTMSAAET ARKTREFRSP PQEQVNMLMN
     FKNCPEEEDC PVPEEVRSGL QLFHNDLLAH CGVHIEEEEE EEQVDTSLRG RLVRLLEKVK
     NLRRRKQEAE PEPEDEKKPS TLQELISHTM IHWAQESFIQ NPELVRIMFS LLHRQYDALG
     ELIRAVPKAY TINAVSVQDT MELLECLSQI RSLLIVQMGP EEERLMIQSI GNIMSNKVFY
     QHPNLMRALG MHETVMEVMV NVLGGGDSKE IRFPRMVTNC CRFLCYFCRI SRQNQRSMFD
     HLSYLLQNSG IGLGMRGSTP LDVAAASCID NNELALALQE QDLEKVVKYL AGCGLQSCPM
     LLSKGYPDIG WNPCGGEKYL DFLRFAVFVN GESVEENANV VVRLLIRRPE CFGPALRGEG
     GNGLLAAIEE AIKISEDPAR DGPSVKKDRR FPMFGGEEQH EENRVHLGNA IMSFYAALID
     LLGRCAPEMH LIQAGKGEAL RIRAILRSLV PIEDLVGVIS LPVQIPAFGK DNSIIEPKMS
     ASFVPDHKAP MVLFLDRVYS IDNQDFLLHV LEVGFLPDMR AAASLDTAAF STTEMALALN
     RYLCSAVLPL ITKCAPLFAG TDHRAIMIDS MLHTIYRLSR GRSLTKAQRD VIEECLMSLC
     RYLRPSMLQH LLRRLVFDVP ILNEYAKMPL KLLTNHYERC WKYYCLPNGW ANFGVSSEEE
     LHLTRKLFWG IFESLAHKKY DAELFKIAMP CICAIAGAIP PDYVDASYSS KTEKKASVDA
     EGNFDPKPVE TTNTIIPEKL DGFINRYAEY THDKWAFERI QNNWTFGEML DENAKTHPML
     RPYKTFSEKD KEIYRWPIKE SVKAMIAWEW TLDKARDGDE DKTEKKAARK ISQTAQATYD
     PSHGYNPQPI NISGMTLSRE LQSMAEQLAE NYHNTWGRKK KMELQAKGGG THPLLVPYDT
     LTAKEKARDR EKAYELLRFL QLNGYAVTRG LKDMEGDVSS IEKRFAYGFL QKLLKWMDIA
     QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILLPLVNQYF KNHCLYFLST PAKILGSGGH
     ASNKEKEMIA RLIFSTDAPA IVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESAADDI
     EKMVENLKLG KVSKGNQPVK GVSQNINYTT VALLPVLTSL FDHVAQHQFG DDVILDDLQM
     SCYRIMCSIY SLGTVKTPHA ERQRPALGEC LAHLAAAMPV AYLEPQLNEY NAFSVYTTKT
     PRERAILGLP NEVQELCLDI PELDILMKEI GHLAESGARY TEMPHVIEIT LPMLCNYLPR
     WWERGLENFP QLEGQLCTDV TSDHLNQLLG SIMKIVVNNL GIDEAPWMKR LAVFSQPIVS
     RAKPEMLKSH FIPTMEKLRK RTAKVVAEEE HLRMEGKSEG DEEEGTIRDE FAVLCRDLYA
     LYPLLIRYVD NNRARWLTCP DPDAEELFRM VGEVFIFWSK SHNFKREEQN FVVMNEINNM
     SFLTADSKSK MSKAGGSDVE LQTSLIVAAL KKMLPIGLNM CSPADQELIN LAKIRYSLKD
     TDEEVREFLQ NNLHLQGKVE NPSMRWQMAL YKEMAGKAED ADAPEKVVKR VQEVSAVLYH
     IEVTEHPFKS KKMVWHKLLS KQRRRAVVAC FRMTPLYNLP RHRASNMFLD GYKRNWLQTE
     GYSFEDRMID DLSKAMEQEE EEEEETETKP DPLHQLILHF SRTALTEKSC HMGEEDECEE
     EDQGGGAEEM SFEVRQSETE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA CKGETGSMVS
     STLKLGISIL NGGNSEVQQK MLEYLKDKKD VGFFLSVQAL MQTCSVLDLN AFERQNKAEG
     LGMVSEEGTS EKVMADDEFT CDLFRFLQLL CEGHNNGQSL YQWFFSVESI SDFYWYYSGK
     EIIDEPGKRN FSKAMTVAKQ VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV GFLHVFAHMM
     MKLAQDSSQI GLLKELLDLQ KDMVVMLLSL LEGNVVNGTI ARQMVDMLVE SSSNVEMILK
     FFDMFLKLKD IVASDAFRDY VTDPRGLISK KDFQKAMDSQ KQYTPSEIQF LLSCSEADEN
     EMINYEEFAN RFQEPAKDIG FNIAVLLTNL SEHVPHDTRL QNFLEQAESV LNYFRPFLGR
     IEIMGASRKI ERIYFEISEV NRRQWEMPQV RESKRQFIFD VVNEGGESEK MELFVNFCED
     TIFEMNIASQ ISEQEEEEKG EDDEEIGDTG EGGGGGGGND EEIGGENGQP ESSSAFADFL
     NGVVNFFGMF TFRNLRRQYR KLRKMTVKEI IISIATFLWT ILLGIFHFIF SVCKGLFLLV
     WHTLFGGSLV EGAKNITVTE ILASMPDPTQ DEVHGDLPGE PGAGEEQEAG GVMDSAEAAG
     GEEEDEESAE KDVGKIPGID TPGGLGDMGD TTPVEPPTPE GSPLTKRKMQ PEETGGEQTT
     VAEEPPPEPE KADTENVEKA EKEVEVKTEE PQETLKVEKT SKAKKEKKMS REEGFELWNE
     LDVQRNKFMN YLSRNFYNLR FLALFIAFAL NFILLFYRVS DTPPGEEFEG SAMFEGSGIF
     ESSGEEIEGS AAEDSMGDDD DEEGPVYYFL EESTGYMQPT LSFLAVLHTV ISFICIIGYN
     CLKIPLVIFK REKELARKLE FDGLYITEQP EDDDIKGQWD RLVLNTPSYP NNYWDKFVKR
     KVLDKYGDIY GRERIAELLG MDLASLDVSK QQTDKKPEEQ DNSMLAWLTA VDLKYQVWKF
     GVVFTDNTFL YLVWYTVMSL LGHYNNFFFA CHLLDIAMGV KTLRTILSSV THNGKQLMMT
     VGLLAVVVYL YTVVAFNFFR KFYNKSEDEN EPDMKCDDMM TCYLFHMYVG VRAGGGIGDE
     IEDPAGDEYE LYRVVFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI
     CGIGSDYFDT TPHGFETHTL EEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWD
     FFPAGDCFRK QYEDQLG
//
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