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Database: UniProt
Entry: W5KNA2_ASTMX
LinkDB: W5KNA2_ASTMX
Original site: W5KNA2_ASTMX 
ID   W5KNA2_ASTMX            Unreviewed;       681 AA.
AC   W5KNA2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   05-JUN-2019, entry version 36.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009064, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000009064, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000009064};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000009064}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000009064};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000009064}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
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DR   STRING; 7994.ENSAMXP00000009064; -.
DR   Ensembl; ENSAMXT00000009064; ENSAMXP00000009064; ENSAMXG00000008820.
DR   GeneTree; ENSGT00940000157997; -.
DR   OMA; MLTALWH; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01044238};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       24     85       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      287    679       USP. {ECO:0000259|PROSITE:PS50235}.
FT   REGION      193    278       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W5KNA2}.
FT   COMPBIAS    239    271       Polar. {ECO:0000256|MobiDB-lite:W5KNA2}.
SQ   SEQUENCE   681 AA;  78188 MW;  13ED099049CB1641 CRC64;
     MDRCKHVVRL RLGHDHSILN PQKWHCVDCN TTESVWACLK CSHVACGRYI EEHSLRHYQE
     TQHPLAMEVR ELDVFCFACG DYVLNDNAEG DLKLLRGALS TVRTSGQRSL RSASCAGELS
     SSFSFCSSQR NGGEGFAPQP AMQAALRHRR RIMLAVAFRR WRNRQLEERR KREEKVEQER
     EELRRQRREV KKRLMEEQAS VPPRKSARLL TQAPRPTLTL IPRKFRDPPE RPPSMLLKQQ
     PLQPLSNKPL SNKPSKPLRN HSNTGKPRRC YVSSSQVRRR RLAPGVTGLR NLGNTCYMNS
     ILQVLSHLQK FRECFLTLDL CETEELLAKT NHPQGVRGVS AGMLGSASAL STLGKQQNNG
     SGELVQPKEP RCSSRQQVSL CHELHTLFRV MWSGRWTLVS PFAMLHSVWN LIPAFRGYDQ
     QDAQEFLCEL LDKVQQELES DGSRKRRIVI PITQRKLSKQ VLKVLNTIFH GQLLSQVTCL
     SCKHKSNTVE PFWDLSLEFP ERYHSLEKAS ACQRSCTLTE MLAKFTETEA LEGCIYACNF
     CNRKRRKSSH KPLALSEACK QLLIYRLPQV LRLHLKRFRW SGRNHREKIG VHVAFDQVLN
     MEPYCCSDSH AALQRQAYTY DLSAVVMHHG KGFGSGHYTA YCYNTEGGFW VHCNDSEMNV
     CSVEEVCSTQ AYILFYTQRS S
//
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