ID W5KND3_ASTMX Unreviewed; 629 AA.
AC W5KND3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Protein phosphatase, Mg2+/Mn2+ dependent 1E {ECO:0000313|Ensembl:ENSAMXP00000009095.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009095.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009095.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR AlphaFoldDB; W5KND3; -.
DR STRING; 7994.ENSAMXP00000009095; -.
DR Ensembl; ENSAMXT00000009095.2; ENSAMXP00000009095.2; ENSAMXG00000008852.2.
DR eggNOG; KOG0698; Eukaryota.
DR GeneTree; ENSGT00940000157884; -.
DR HOGENOM; CLU_013173_15_2_1; -.
DR InParanoid; W5KND3; -.
DR OrthoDB; 202023at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000008852; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR13832:SF535; PROTEIN PHOSPHATASE 1E; 1.
DR PANTHER; PTHR13832; PROTEIN PHOSPHATASE 2C; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 138..395
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 398..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..438
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 70348 MW; A0C87BDC08D05425 CRC64;
MAACGSEEKT YRRFLELFLR EMKPPLPEDG PLPTRPLSDS LAEDEVEGET LELCLQHLCK
YNCPFTLAAA LARGTADSVL QSDLSVYHLN KNTEDGTETF PQIEAVKLAR LVFNKLCETC
CLWLKGVPIR RRAQPYYETS IHAIKNMRRK MEDRHVVIPD FNSLFNLQDQ EEQAYFAVFD
GHGGVDAATY AANHLHVNLV RQEMFSQDPG EALCRAFKLT DERFVQKAKR ENLRCGTTGV
VTFLRGRTLY VAWLGDSQVM LVKKGQPVEL MKPHKPDRED EKQRIEALGG CVIWFGTWRV
NGSLSVSRAI GDSEHKPYIC GDADHISFPL DGTEDYLILA CDGFYDTMNP EEAARVVSDH
LQENSGDTTM VAHKLVASAR DAGSSDNITV IVVFLRDPRA PPPSEEPEEE GEEPEEEPVE
EEAEPEEEEG EEEETSQSEL VCQDGGGENG GKSRGGWPLQ QCSAPADLAY EDRMDSFTDR
TSLSITGPKP FTEKGCFQLP SEPGSPPSRT FSPDLGPGGG WVWRPRMEAE GICGLRHQKR
PKSLVPPFTN SATGRWLEAA ALFPQQGRRK RRMEGASLKR EMKKRRPILT AQKSHCPLSP
HPYVPFPLRC IDSRPGVAMP RVTHDEYGV
//
