ID W5KNU3_ASTMX Unreviewed; 1418 AA.
AC W5KNU3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=YTHDC2 {ECO:0000313|Ensembl:ENSAMXP00000009255.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009255.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009255.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR SMR; W5KNU3; -.
DR STRING; 7994.ENSAMXP00000009255; -.
DR Ensembl; ENSAMXT00000009255.2; ENSAMXP00000009255.2; ENSAMXG00000008735.2.
DR eggNOG; KOG0920; Eukaryota.
DR eggNOG; KOG1902; Eukaryota.
DR GeneTree; ENSGT00940000155826; -.
DR HOGENOM; CLU_001832_1_6_1; -.
DR InParanoid; W5KNU3; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000008735; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 29..97
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 196..362
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 601..777
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1277..1407
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 159681 MW; A8D7A983A783D36C CRC64;
MSRPNAGSHK PNRSSSKQSD SLRSKGLKDI RIDEEVKIAV NIALERFQYS EEKEMEFPSS
FTNSERAFVH RLAQSLGYIS KSRGKGSNRF LTIWKKDGSE AAQSIMTFSF TANSKHVARN
LLQRFPITSK ERTDLLPRTD RGLSLSLDTG DGSRDKNRTN GRLQKGLPQV PQRRGPSELE
SFRRTLPVYE RQEEIVATIK ENQVVLVVGE TGSGKTTQIP QFLLDDSYQK GIPCRIFCTQ
PRRLAAIAVA ERVAAERGES IGQTVGYQIR LESRVSPKTL LTFCTSGVLL RTLMSGDATL
STVTHVIVDE VHERDGLTDF LLTKMRDMLQ KMPSLKLILS SAALDVDLFI RYFGKCPIIH
IKGRPYDVKP LYLEDILRTT SYMNKDMVRY KKEMQKEEKQ QTSLTEWCEV KEGVSRPEPQ
RDRRPACVLQ ENDLLYDGGD SVFSQLNEKD VASLEPWLLK EMDTCISEIF LEQDADAFVQ
LFNLILNENI SVDYRHSETS ATALMVAAGR GFICQTEQLL SMGANVHIKA SNGWTALDWA
KHFNQTEAVD LLESHISSLE AGQLDESSLL QSSSGELSAE DQELLKAYHH SFDDEKVDLD
LIMHLLYSIC QSSDEGAVLI FLPGYDEIVG LRDRILFDDK RFAEHQHRYQ VFTLHSNMQT
SDQRKVLKPA PSGVRKIILS TNIAETSITV NDVVFVIDSG KVKEKAFDAL NHVTMLKMVW
ISKASALQRR GRAGRCRPGI CFHLFSRLRF KNMLEHQVPQ LLRMPLQELC LHTKLLAPID
CSIAEFLSKA PEPPHLMTVK NAVQMLKTID AMDPWEDLTE LGYHLADLPV EPHLGKMVLC
AVVLKCLDPI LTIACTLAYR DPFVLPAQAS QKRAAMLCRK RFAANTFSDH MALLRAFQAW
QKARADGWER SFCENNFLSQ ATMEIIIGLR TQLLGQLRAI GFVRARGGGD IRDVNLNSEN
WAVVKAALVA GMYPNLTHVD RESLTLKGAK EKKVRFHPTS VLSQPQFKKI PPANAQAAAV
QSLPSDWLIY DEMTRAHRIA SVRCCTAVSP LTVAVFGGSA RLPSTAFQEP TMAKAVNDSV
NESSDSEMED RSTAHLAQIK IDEWINFKLD REMADLVFQL RLRWQGLFLR RISSPSKQWS
QLDEATIRTL VSVLSAEEQV TGLQQPTGIG QRPKPMPSDK SPPRSTWKST NSRRGFMESE
LDEEAAGCGD RSSRQSPTPS QSKHYRDKGA AHHKRSADDR LSVKSDSPSF NTPCASPSST
SSGKCSKSPP QRPPAPVRYF IMKSSNMRNI ELSQQRSIWS TTPNNEHKLN RAFQESSMVF
LIFSVQGSGH FQGYARMSSE IGLERCQDWG SSGLGGVFRV EWIHKESLPF QFTHQVFNPW
NDNKKVQISR DGQELEPQAG AQLLQLWDRI SIKQQHEL
//
