ID W5KQ72_ASTMX Unreviewed; 786 AA.
AC W5KQ72;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009734.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009734.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; W5KQ72; -.
DR STRING; 7994.ENSAMXP00000009734; -.
DR Ensembl; ENSAMXT00000009734.2; ENSAMXP00000009734.2; ENSAMXG00000009469.2.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000160877; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; W5KQ72; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009469; Expressed in embryo and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 2.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 2.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF363; SERINE (OR CYSTEINE) PROTEINASE INHIBITOR, CLADE A (ALPHA-1 ANTIPROTEINASE, ANTITRYPSIN), MEMBER 1, LIKE PRECURSOR-RELATED; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 2.
DR SMART; SM00093; SERPIN; 2.
DR SUPFAM; SSF56574; Serpins; 2.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 95..451
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT DOMAIN 514..784
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 89211 MW; 61E386B2A1D84686 CRC64;
MLVVGLMFKS SSSPSKTIKG WDCIKTVSCG QDTSGDKMWG KGCFLGALLL TVAWAAPQGN
HDQHLHHGKD EPHPSHEGED DICHRLSPHN ADFAFSLYKK LSTHPEAKGK NIFFSPLSIS
MALSMLALGA KGNTHSQIFS TLGYSTLTPD QVNEGYEHLL HMLGHSQEAM LLEAGSAVAV
REGFKPVDKF LKDAQHFYQG EAFTVDYSKP EVAVQEINKY IAKKTKDMIT DMVKTLDQQT
VMMLINYIYF RGKWEKPFEV EHTHKADFNV DENTKVSVDM MKRTGRYDFY HDRENSTSII
MVPYKGNTSM MIVLPEEGKM EELEKHICKD HLRNWHGKLF RSSVDLFLPK FSISASSCLV
ETLKEMGMVD AFSDTADFSG ISEETKLKAS KVLHQAVLKV DEKGTEAAAV TTIEIMPMSL
PDTMILNRPF LVFIVEDSTK SILFMGYKMW GRLYSCFLVS LLLMVVWAAP QKDHDHSEDH
HQHLHHGKDE PHPSHEGADD LSHRLSPHNA DFAFSLYKKL STHPEAKGKN IFFSPLSISM
ALSMLALGAK GNTHSQIFST LGYSTLTPDQ VNEGFEHLFH MLDHNQDAML LEAGSALAVQ
EGFKPVDKFL KDAQHFYEGE AFTVDYSKPE VAVQEINKYI AKKTKDMITD MIETLDPQTV
MMLINYIYFK GKWEEPFKAR LTHKADFNVD ENTKVSVDMM SRTDLFDFYR DQENSTSIIK
VPYKGNTSMM IVLPDEGKME ELEKDLCKHH LKHWNEKLSG RPVDLRMPRF NTSASINLEK
LCLKWE
//
