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Database: UniProt
Entry: W5KQW2_ASTMX
LinkDB: W5KQW2_ASTMX
Original site: W5KQW2_ASTMX 
ID   W5KQW2_ASTMX            Unreviewed;       507 AA.
AC   W5KQW2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   18-SEP-2019, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000009974};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009974, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000009974, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000009974};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000009974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000009974};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000009974}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   STRING; 7994.ENSAMXP00000009974; -.
DR   Ensembl; ENSAMXT00000009974; ENSAMXP00000009974; ENSAMXG00000009701.
DR   GeneTree; ENSGT00970000193368; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR003276; K_chnl_inward-rec_Kir3.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF17; PTHR11767:SF17; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   DOMAIN      112    251       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      258    426       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1    110       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      448    507       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     48     72       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    487    507       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   507 AA;  56571 MW;  FB8C20D2A5AA05CD CRC64;
     MALENSTFSS RPESLSLPVP EKGEEPAEEA KEDAPPPTGV FNVSEELGHV VTTETSPAPQ
     PPTSNNMSFQ DKMAAREAQA NQPRKKLQGA GQERGKFGWG RSKRKRKRQR YVEKNGRCNV
     QHGNMRETYR YLTDIFTTLV DLNWRCSLFV FVMAYAVTWL FFGAIWYLIA YCRGDLDHLQ
     DDTWTPCVDN VNSFISAFLF SIETETTIGY GHRVITDQCP VGTMLLLLQA ILGSMVNAFM
     VGCMFVKISQ PNKRAETLVF SRNAVISLRD DKLCLMFRVG DLRSSHIVGA NMRAKLIKSK
     QTQEGEFIPL DQTDISVGFE TGDDRLFLVS PLVISHEVDS RSPFWDMSQS QLEKEDFEIV
     VILEGMVEAT GMTCQARSSY LAEELMWGHR FSPMMSLAEG FFDVDYGAFH HTFEVDTPSC
     SARELALAAA RLEAHLYWSI SSRLDEEKWE GPNLTDQSGK PTDSESVSGK EGGGPTFIVG
     GVTETPEQSV VGEQNGSVTT DQSESEA
//
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