ID W5KRG1_ASTMX Unreviewed; 721 AA.
AC W5KRG1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Neural cell adhesion molecule 1b {ECO:0000313|Ensembl:ENSAMXP00000010173.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010173.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010173.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This protein is a cell adhesion molecule involved in neuron-
CC neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
CC {ECO:0000256|ARBA:ARBA00003000}.
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DR AlphaFoldDB; W5KRG1; -.
DR Ensembl; ENSAMXT00000010173.2; ENSAMXP00000010173.2; ENSAMXG00000009903.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155743; -.
DR HOGENOM; CLU_010961_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009903; Expressed in camera-type eye and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR009138; Neural_cell_adh.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR12231:SF239; NEURAL CELL ADHESION MOLECULE 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR01838; NCAMFAMILY.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 15..103
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 108..181
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 204..289
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 294..387
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 392..487
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 486..590
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 592..687
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 572..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 79587 MW; 42B5CF17CA172E78 CRC64;
RLRNKDMYGY VHVSLQVDIT PAQGEISVGE SKFFLCEVVG GVKGIDWFSP TGEKIEPNRQ
DITVIRNDET SSTLTIYNAN VDSAGTYKCV ATSGDQQAEA TVNVKIYQKI AFKNAPSPQE
FTEGDNAIIV CDVVSSPPPT VIWKHKRVKV QSEKDVRFKI LNNNHLQIRG IKKTDEGVYN
CEGRVMTRGE IDFRPIRVVV NVLPTVRVRQ AEVNATADLG LSAMLACDGD GFPEPTVMWK
REEEEEEEEG FNEDGSEMTI MDVKKLDEGD YTCIASNKAG KAEEEVSLRV FVKPRITFLE
NQTATEMEEQ MTLTCEATGD PTPTITWSYG TRTFTEGEQS ADGMVVVRSD ARVSSLTLKY
AQYTDAGEYL CTARNAVGET SQHMYLEVHY APKILGSVAV YTWEGNPANI SCETLAHPSE
VSIVWLRDGF TLPNANTSNI KIYNTPSASF LEVNPDSQND FGSYNCTASN VIGTESKEFI
LIQAEVPSVP VITQVQPYSS TAQLLFDEPE SSGGVPVLKY RAEWKAMNRN NWVQRVYEVR
EGTSASYGGL NAITITGLKP ETQYEAKMSA INGKGEGESS STVSFKTEPV REPTPPKLEA
ILQPKGNALR VNWVKQDDGG SPITHYLIRY KADPIWKPEI RLPSVSEYVL LSSLDWNTEY
EVFVVAENQQ GKSKPGILTF RTSSKRDAIP GELGVEGVQS LFVSLLHPSR SSPAAPAAAC
Q
//
