ID W5KRR8_ASTMX Unreviewed; 855 AA.
AC W5KRR8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010280.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010280.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KRR8; -.
DR Ensembl; ENSAMXT00000010280.2; ENSAMXP00000010280.2; ENSAMXG00000009944.2.
DR GeneTree; ENSGT00940000164468; -.
DR InParanoid; W5KRR8; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009944; Expressed in brain.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF342; PROTOCADHERIN GAMMA-B1; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..855
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017198706"
FT TRANSMEM 681..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..127
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 128..236
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 237..341
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 342..446
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 447..556
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 571..669
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 819..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 94223 MW; A79BC1388D7CF40D CRC64;
MQPAMMWHKV LFFVVICSHS ALGQVSYSIP EEMAKGSMVG NIAQDLGLDL KRLKTGKALI
FSGDSTEYIE LNRERGMLLI KEKIDRESLC AKTTPCALHL QMILENPMEM YTITVEITDI
NDNAPIFQKG DISFEISESA IIGARFMLDG AVDADVGPNG LQSYSIQPTD HFVLEMQSHA
DGGKNVEMVL KRPLDRELNE RFTLLLTAID GGQPVLSGTV QIHVTVLDVN DNAPIFTQKV
YKTSVIENSI KGTKLTTVSA SDADEGSNGQ VTYFISNLNE DGKEIFMINR ESGEITLSGQ
IDYEKTTQYQ LDIKAKDQGG LADSCKVNVE VIDINDNNPT ITVMSISNSI SEESPPSTVV
AMMKVYDPDS SVNGQVHCSI AENIPFLIIS TSNNFFSLRT DQELDRERNA EYNITVICSD
EGVPSLSSIA SLHLQIIDVN DNAPVFERRS YEAFVVENNT PGLSIFAVKA RDADSNQNAR
VSYILEDSTV NGVPVSSYLS VRADSGLINS VRSFDYEQFK NFHFRIIAQD GGSPPLSSNV
TVTIKIRDQN DNAPQVLYPV QTGGSMVAEI VPRSADVGYL VTKVVAVDVD SGQNAWLSYK
LQKATDRALF EVGPQNGEIR TVRQVTDKDA VKQKLTVVVE DNGQPSRSAV VNINVAVADS
FPEVLSELID FSHGKEYNDN VTFYLVLALA AVSFLFITCV VVIISVKIYR WRQSRVFYQS
NLPVIPYYPP GYTDTGVTGT LPHMFNYDVC MTTNSRKSDC KYSTLGGQSV LMVDPSFTET
MQRAMVDNGL YEDPDSAQLV RAFIRSLSNN DAEPLLKHAL DSPTHTTLNN QRKKSSPRVS
VSPTSTLNIL VSCPR
//
