ID W5KS00_ASTMX Unreviewed; 666 AA.
AC W5KS00;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=GRB2 associated binding protein 2 {ECO:0000313|Ensembl:ENSAMXP00000010362.2};
GN Name=GAB2 {ECO:0000313|Ensembl:ENSAMXP00000010362.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010362.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010362.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR AlphaFoldDB; W5KS00; -.
DR STRING; 7994.ENSAMXP00000010362; -.
DR Ensembl; ENSAMXT00000010362.2; ENSAMXP00000010362.2; ENSAMXG00000010088.2.
DR eggNOG; ENOG502QTS1; Eukaryota.
DR GeneTree; ENSGT00940000157792; -.
DR HOGENOM; CLU_028652_0_0_1; -.
DR InParanoid; W5KS00; -.
DR OrthoDB; 2904117at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010088; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF1; GRB2-ASSOCIATED-BINDING PROTEIN 2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 5..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 236..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 73255 MW; 088E9C0BC1D36DB5 CRC64;
MSGGEIICQG WLRKSPPEKK LRRYAWKKRW FILRSGRMSG DPDVLEYYKS DHAKKPIRII
DLHCCEQVDA GLTFKRKEFQ DSFVFDIKTA ERTFYLVAET EEEMNRWVRS ICQLCGFNQS
EDNHDERPST THMLRSIAGD LGGSMAPLIG ERKTSAPSHS SQPMLFTFDM PVRHSHGSLS
NSAPQDYLLL HQCMSRKSES ARSASFSQAS RGSLLVGSDS AVQRLTHGLS HCLNGTGTYS
LPKPSKSQQL GSPRDGCYVL PRGYSSEGAS ELDSDEVYTY KTPCNALATS HFNEQRPPDN
YDLPTTPGSF YQIPRTFDRN HNALTPSSAD STGGPPPRPP KPNQSSETRW GSPQSLGGQN
GEVSNVSVIP RRNTLPAVEN IRLHRGSSFE TSSHQRPIYF NNSGQSVESV NDGFSSYLRA
KAPLTRSDSG NSDDNYVPMN PGSSSSPLNA ALADSPKNNY IPMSPGPHHF DFPGFSATLP
ARKGSTASLC HRPGRLSDVT PPPINRNLKP NRKAKPTPLD LRNNGIIDEL PFKSPVTLSW
TRPMPIMNSI SSQHCRPIST QSITSTDSAD SEENYVAMQN PASTSPAVSG TSSPAPRKCG
NVDYLALDFQ PGSPGPHRKP STSSATSDEK VDYVQVDKEK TQALQNTMQE WTDVRQSGEP
TKGIKS
//
