ID W5KS86_ASTMX Unreviewed; 649 AA.
AC W5KS86;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=CD2 associated protein {ECO:0000313|Ensembl:ENSAMXP00000010448.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010448.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010448.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KS86; -.
DR STRING; 7994.ENSAMXP00000010448; -.
DR Ensembl; ENSAMXT00000010448.2; ENSAMXP00000010448.2; ENSAMXG00000010175.2.
DR eggNOG; KOG4348; Eukaryota.
DR GeneTree; ENSGT00940000157566; -.
DR HOGENOM; CLU_024255_2_0_1; -.
DR InParanoid; W5KS86; -.
DR OrthoDB; 2972088at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010175; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR GO; GO:0039021; P:pronephric glomerulus development; IEA:Ensembl.
DR CDD; cd12056; SH3_CD2AP_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR035777; CD2AP_SH3_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF23; CD2-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 131..190
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 288..349
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 189..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 72279 MW; 5782E25BB2956F7C CRC64;
MVEVVVEYEY EAAHEDELTL RQGDIIKNVR RIEEEGWMEG DLNGRRGLFP DNFVKEVRKE
PVKEEVKEAK EVKEAKETKE VKEVKEVKEV KENAQPQRRS AGNVASLVQR ISTYGIPTGG
LGFQPRSSKK KKKRQCKVVF EYVPQNEDEL ELKVGDIIEI TEEVEEGWWS GSMNGKSGLF
PSNFVKEVEM NEEEEISDVP DDPDSKDEAM SPTSPHPGNG VIAQPKKVKG VGFGDIFRDS
VKLKVRLPSE TEDKKEKPIP SLPSAAKPTN LSTSDAQKLE KDGESKGKVK EYCKATFAYE
ATNQDELDIK EGDVIHLLSK DTGEPGWWRG ELSGKQGVFP DNFVVLLSES DKEPLASKGS
VKQSPKQEPE EKPKKPPPPS KSTVLKPEVP SAERKPPQPR PEDKVDRAIP EKPAKPAAPI
VPPKKPVPPP GKGLIRPGSL TPKRPDKPLA PSPVAKHNGE VPHLRPKSDL EPTLPSKPKT
LSGDWAEKVV ESDLMSFDDV SSTSEKLSHP TTSRPKMPGR RLPAQFGGHS PSKEASEKVQ
KTEEEEVPRP KSSESWKPSL PTPTPAVHNK VVSTSTPEPK PKAEGEEEKR GEVEELRTQL
KELALSIELL KTQQTRELSE LRNELDEERL KRVALQLEIE KLKKQVQST
//
