ID W5KSH8_ASTMX Unreviewed; 399 AA.
AC W5KSH8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Proteoglycan 4b {ECO:0000313|Ensembl:ENSAMXP00000010540.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010540.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010540.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KSH8; -.
DR STRING; 7994.ENSAMXP00000010540; -.
DR Ensembl; ENSAMXT00000010540.2; ENSAMXP00000010540.2; ENSAMXG00000010261.2.
DR eggNOG; KOG1565; Eukaryota.
DR GeneTree; ENSGT00530000063751; -.
DR HOGENOM; CLU_008106_0_0_1; -.
DR InParanoid; W5KSH8; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010261; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00094; HX; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 1.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR018486; Hemopexin_CS.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF1; PROTEOGLYCAN 4; 1.
DR Pfam; PF00045; Hemopexin; 1.
DR SMART; SM00120; HX; 3.
DR SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR PROSITE; PS00024; HEMOPEXIN; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REPEAT 216..263
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 1..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 43976 MW; 5E3065F74A028A38 CRC64;
MPNSDHSDLP PTPTNTAQAA QLATTTALPD QNTQTNSPEL KPSNPDQPEG TVAPEDNPDQ
PEGTVAPEDN PGPQTEQPAQ PEPTTSAASA GVEPKDLDPT EIPITTETPK TKESTRGPPT
THDLSITPDS VKQDPSPSKE AEKPTKPKPE AKDVLDEGNP QDYQSDTNLC SELPVNGLTT
LRNGTIAVFR GHYFWMLDSR RRPGPAQSIT DVWGIPSPID TVFTRCNCQG KTYFFKGNNY
WRFENDVMDP GFPRPVSEGF GLGGQITAAL SMPQYRSRKE SVFFFKRGGL AQRYSYRVTP
QCGRNLAVYT TKKKVKRQAV PELGQEIDIR KSLRGFPYTV SSAISVRSPG GDGYKYYVFS
KSKYYSLKME GDTPVILTPR SGPGQQKPEK SWFRCQKTL
//
