ID W5KSK2_ASTMX Unreviewed; 496 AA.
AC W5KSK2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Docking protein 2-like {ECO:0000313|Ensembl:ENSAMXP00000010564.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010564.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010564.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KSK2; -.
DR STRING; 7994.ENSAMXP00000010564; -.
DR Ensembl; ENSAMXT00000010564.2; ENSAMXP00000010564.2; ENSAMXG00000010283.2.
DR eggNOG; KOG4047; Eukaryota.
DR GeneTree; ENSGT00940000155980; -.
DR HOGENOM; CLU_030101_3_0_1; -.
DR InParanoid; W5KSK2; -.
DR OrthoDB; 2996885at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010283; Expressed in zone of skin and 9 other cell types or tissues.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF46; DOCKING PROTEIN 1; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 143..247
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 244..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 55578 MW; 0E82B6912D2335FB CRC64;
MDTFMKRGEV YLQHHKHSEK WKRYWLNLYP GSRNGVARLE LTETSSDRSP AMVRRQPDRK
VIRLSECISV VRLPPHAEAH PGDNMAAFCV QTDDKRMVFA VEKERCGEWV EKICDIAFQK
GSSSIPRQVP QMEENQIYAS REEVFDFWVT LQQSEAAVRC GLQGAYWLQT GEESLIIQDT
ESRQRVIEWP YKLLRRYGGD KTVFSIEAGR RCESGPGTFV FETKQSEEIL RRVEQAIQQQ
KTLSVSAGSC SPRSPCSPLP RRPISASLLD TLANSSGLSS SESSANNDGP GGLADSAFVK
AATGTSKTNP RLPGESTGMP EPIYSTPIDD IAFRLQQPTV KNGRPIHHPY EYTEPVYSDP
ADVIRPNPNA RMCAWSNTTD TVSVPVPLES SHHSPQPDPL YSEVLHIMPN PAQQPVSQAQ
NKEEPIYSLP IHNTVHKSCE DVQTASESKS DMENRKVDEI TAIYSQVNKA AKTKKPKDKT
ESQRVPDVVS EPLGWI
//
