ID W5KSL4_ASTMX Unreviewed; 588 AA.
AC W5KSL4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Autophagy-related protein 16-2-like {ECO:0000313|Ensembl:ENSAMXP00000010576.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010576.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010576.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KSL4; -.
DR STRING; 7994.ENSAMXP00000010576; -.
DR Ensembl; ENSAMXT00000010576.2; ENSAMXP00000010576.2; ENSAMXG00000010298.2.
DR eggNOG; KOG0288; Eukaryota.
DR GeneTree; ENSGT00940000153936; -.
DR HOGENOM; CLU_000288_57_10_1; -.
DR InParanoid; W5KSL4; -.
DR OrthoDB; 458014at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010298; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF7; PROTEIN ATG16L2; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 299..340
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 343..377
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 385..426
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 523..552
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 215..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 66089 MW; C6DD15DE04562AC8 CRC64;
MMAATEPEKP VCRKSPESWK RHIIRQLKSR DKAQKILFQD VIRSYVNLLE RCTQKAFITK
GILSATRPLL LPSSEDSLKT ATGELAYQVV ELRQEIKIKE AILDKQHARL NELQDGLKAG
QVEHSTLQTC VLEVQERNQL LKRDYDTLLE CCQHMDAVYR KEKLHGSELV EDMVRWKQQA
AARMNSRNER RVRAREAGRH KELEVAASKK LNIEEIPQSA SLPSSPLSPR SETGEKVERS
HGRLFRSASA SSPRILGSIR DLFDKKRRGN SVCSLEEDLF TPLGICLAAR VPAKAIYSLD
AHEQGINAVR FSPRSNLLAT GGTDRVIKLW DIKAGMLHNR GTLDGSNEGI TSIEFDSTGT
RILAASYDKS ALFWRLDDCV PKFTLTGHSR KVTAARFKCN LRQVVTGSAD RTVKIWDLQR
TACIQTIEVL SYCSDVVCSE YYIISGHYDR KIRFWDSRAA SCTQEVPLQG KVTSLDISPN
HRELLSCSRD ESLQLVDLRM SNTRMAFRAE GFKCGSDSTK AIFSPDGSYL VAGSADGAVY
VWNVSTGKLE TRLSDKHRCS VNAVAWSMSG EYVVSVDKSR RAILWSDI
//
