ID W5KSX7_ASTMX Unreviewed; 1227 AA.
AC W5KSX7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Protocadherin 1a {ECO:0000313|Ensembl:ENSAMXP00000010689.2};
GN Name=PCDH1 {ECO:0000313|Ensembl:ENSAMXP00000010689.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010689.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010689.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KSX7; -.
DR Ensembl; ENSAMXT00000010689.2; ENSAMXP00000010689.2; ENSAMXG00000010404.2.
DR eggNOG; ENOG502QWB7; Eukaryota.
DR GeneTree; ENSGT00940000155521; -.
DR HOGENOM; CLU_006480_5_3_1; -.
DR InParanoid; W5KSX7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010404; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF247; PROTOCADHERIN-1; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 852..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..167
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 168..279
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 280..386
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 395..505
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 506..611
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 612..714
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 729..834
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 883..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1227 AA; 133061 MW; 6F0502028B55DD37 CRC64;
SLEGRSSQRC LLALVGSLSS SLCGPAHPKP SGLGGVMDFS VGWFLLFALL VDSINSALGG
ILYHVREEQP PNTLIGSLAA DQGLPDSGHL YKLEVGAPYL RVDGKTGEIF TTEIPIDRET
LKDCRIKGKP CFLEFEVSVT DLIQNQSPRL IEGRIEVQDI NDNTPQFPSP VLTLSVQENA
HMGATFAIPQ ATDRDTERNG VLKYDLSAGP EASALFSLQM ANDRGEKLPQ LIVLGNLDRE
LKDSYDLTIN AVDGGTPSRY SSALLRVVIT DANDNAPQFE KSSYEAEVSE NSPVGYSVLQ
VKANDSDLGP NGEIEYTIHQ ASDPVPKMLQ IERSTGIISV KGPLDREEIS SFKFHVIARD
KGPSPKSSTT YVSIEVTDQN DNAPAVEIRG IGLRTHSDGV ANISEDMPVG TAVALVQVSD
KDEGENAVVT CVVAGDVPFQ LRPAGDSSVD NKKKYFLQTT TPLDYERIRD YRVEIVAVDS
GNPALSSTNS LRVQVTDTND NSPIFSPPLF EVEFAEENQP GEKVLDVIAL DADSGTNAEL
VYSIIADSST RGLFEIDPSS GEVRARSPLD REHKERYEFR VTAADKGVPS HRGTATVVIK
VLDRNDNDPK FMLSSYSFSV LENMPPLSPV GMVTVLDMDK GENAQVQLSV EPDVGNFVVQ
NGTGTILSSI SFDREKESSY TFRLKAVDGG EPPRSSYVGV TINVLDENDN APVVTKPSNS
SFRRLSPLAA PDSVVEVVEA EDIDYGSNAE LVYSIAGGNP HELFYISPSD GEIKLTKELT
RKHGGLHRLV VKVSDRGKPS RHAIALVHIY VNETISNVSL VEGLVGHSLY TPLDTDIAGD
PDYGLAAQRS NIVYGSLAGV AGVVTVIIVV VFIRHRLQRE TKSGYQAGKK ETKDLYAPKQ
GTKSIKGKKG RKGKPPKSPK PLGEDEEVSL QKSLKFNIDG VNDSPRIHLP LTYPPSSPDL
GRHYRSNSPL PSIQLQAQSP SASQKHQAVQ ELPATNTFVG TGGDDNSTGS DQYSDYSYKT
NQPKYSTKSL PHRRVTFSTA NPVQDLQDSS QQSYYDSGLE ESETPSSKSS SGPRIGPLAL
PEDHYERTTP DGSIGEMEHP ENDIRSLPDV AMTGNCSQEC SELGHSDACW MPGQPSPVRK
SRNPPKLSTF VPYQERGSLG RLANGSAPRL VADESRPRLP PSRSAYSSSD HVSSDHAPLE
KVPLSVTSEF PPTSPPSNHT SKREIYL
//