ID W5KTE1_ASTMX Unreviewed; 1311 AA.
AC W5KTE1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Alpha-2-macroglobulin-like {ECO:0000313|Ensembl:ENSAMXP00000010853.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010853.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010853.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR Ensembl; ENSAMXT00000010853.2; ENSAMXP00000010853.2; ENSAMXG00000010569.2.
DR Ensembl; ENSAMXT00000049777.1; ENSAMXP00000030639.1; ENSAMXG00000010569.2.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000162996; -.
DR HOGENOM; CLU_361927_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010569; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF150; ZGC:171445 PROTEIN-RELATED; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1311
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041119144"
FT DOMAIN 463..612
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 741..830
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1311 AA; 145332 MW; 6F25A6B2E98010BB CRC64;
MAVGGLPVRE GLLLACLLFL PVYGEPSGPY FMVTFPAVIE SGSEAKLCVS LLKPNETLQL
TVYLLYNNQN RTLLQERVKE EFHRCSQFKA PEIEGQSIQE IRVEVKGESF VMTEKRKVMF
KSYNPLTFIQ TDKPIYNPGQ TVHFRVVTMG ADLVPLEEEY NILTLADNKG NRIGQWTNVS
STGLILQLSH QLNSEASEGQ YKLEAITEDR SITHFFTVKK YVLPRYEITV KVPKEQSVGE
EDLKIEVCGK YTYGQPVPGK ARVEVCRKFE RYYYEGVQMI TPCLHENVEM DEDGCATHVF
NMSLFSNSEF EHNFRDSLDI NVVMTEEGTG ISMVKSERTS VTYEIGKAEF LDLPKNFERD
TVIEGKIKVV TYGGEPIRNK EVYLLKGPSW SPTLLLNLTT DDDGLAKFAV DAPAEPETEI
LLLASVYPGN QYQGYKKPFF RNSDARIQVL QPATPYSPVY SEISIESLEE PIKCDSEVSV
HFKYYIIGES TENYSTDLIY TVISRGVIVH HGYKKVEVKE SRRLIEGRVS FKLSVVPEMA
PVVQVLVYGV LPSENVIAAS KNFKVDKCFT NKVSLQFSPS EAVPGEENSL QLSALPGSLC
ALSAVDQSVF ILEPGKRLDP DTVFNLLPVT SVSGYTYEVE DEQECLHVRP RRNAQVDRAY
NAIKSVGLKM VTNLAVREPQ CLVYKGVEYH RGGYGWRYDS RVGMAGPGAP PVALAMGVAM
SYESEDSDNS YETVRKFFPE TWIWQLAEVG GSGSAQVPVT VPDTITTWEM DTFCLSSRGV
GVAPAAQLRV FQPFFLELSL PYSIIRGEEF ELKATVFNYL SKCIMVKVTP APSSDYTLKA
SSSDEQYSSC LCANGRKTFR WTLVPSVLGV LNVTVSAAAE ASQTVCDNEI VSVPDRGRID
TVTRSLLVKA EGTENSKSQS WLLCPQGNSV SEELELTLPE NVIAGSARAS VSVLGDILGR
ALKNIDGLLK MPYGCGEQNI ALLSPNIYIL QYLENTQQLT PAIREKATGF LKSGYQRQLN
YKHFNGAYST FGRGEGNTWL TAFVLRTFGK AQRYIFIDPE NIDQTKQWLI SKQGPDGCFI
RQGRLFNNRM KGGVNDNVTI TAYITASLLE LGHKAEDPLV IKGLSCLKSS LGTINTYATA
LLAYTFSLAG ENEIRGQLLK KLDGDAISGD GRLHWSQSAS EDSDSLSVEI SSYVLLAVLS
TDKLSNADLG YANRIVSWLV RQQNPYGGFS STQDTVVALQ ALALYATKVY SPDGSSTVTV
QSADKETHSF EVNQNNKLLY QEKSLQNVPG KYSVLVNGTT CASVQVSVCL L
//
