ID W5KTS9_ASTMX Unreviewed; 1107 AA.
AC W5KTS9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=WWC family member 3 {ECO:0000313|Ensembl:ENSAMXP00000010991.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010991.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010991.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KTS9; -.
DR Ensembl; ENSAMXT00000010991.2; ENSAMXP00000010991.2; ENSAMXG00000010683.2.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00410000025556; -.
DR HOGENOM; CLU_005420_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010683; Expressed in heart and 14 other cell types or tissues.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF25; PROTEIN WWC3; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 15..48
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 62..95
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 635..759
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 145..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 125073 MW; E7990C9A329513B1 CRC64;
MPWESGAKRR ESSELPLPAG WEEARDYDGR VFYIDHNTRQ TSWIDPRDRI TKPLTFADCV
GDELPLGWEV VYDQQVGVYY IDHINKTTQI ENPRTQWRQE QEHMLKEYLV VAQEALKAKQ
EMYQIKKQRL ELAQQEMQLF NQLNQDDNRS ITSSHSGSSS NAKYDPDQIK AEIACRRERL
CRLKQELAQM KQELQYKEMG VETLQEIDRK MSSSQTNYKL DEAQAIFNEL RSIKKAISSG
EKERQDLIQV RRFSSTDADS SPLVDKVKLN WQFEEAKKKV SSIQHQLAQL DSESWSGRAE
ADRDHDCLQL LREKEAFLQE LTLLCQQQQP PEVFLQLDEE RRKLEEEVQK AHSTQSQGAN
QRILQQEKRN VLLRQLEEAT RVTTYLHSQL KSLSASSLTV SSSSSRGSLA SSRGSLASSR
GSLSSISFTD IYGLPQYERQ EGCMDIQDPT FRYLLPVEAP CRDTSSFGPK RAHDAPQSLT
SLSSRSSLSS LSPPSSPMDT PYHSGPQDCP LTQMTEEYME LAGRGLVLEG LRGQTQTQQQ
APLSGEGEAG SSSTAHLLEG KGHRDTGVQG PYSSTGVTLR SNSVNRSGRR ARRVSAGVSE
DVLATDSGVF EAWSRSRTEE TEEVMFTRDA ISAPEPPQVQ LGLLYDSTSM SLLLHVLQMR
NLSKATVRDS YKVYVKVNVL PVDSSRPCTY YCCKAQEPRS AFSFNEGFQI PLPAGAAGPH
ALNLQLCALG PHGHEELLGS VQVVLADCAG STEMVFQWHR VQLLQQTTCS VENHRPDPSS
LCQPSHSVDE EEEEEDEEHG MSVSAQLEEV KRGLELSEEE LERKEEQGEA VSERSWQAES
VDSGCSNSTA FVTPCPEGFC AEGICIATGG RCIPHSDRSH IIKVDKATNT ELIRMQPKER
PGALGSCTSF PAQQHASSLT HVLTWSPQPV CLQSDCTAVT VTAPLYQKKS PFIRNTLERR
TLRYKQQPHR TSLAEQPTRT SLDLELDLQA CRTRQRQLSE ELTALRELKL RLEDPAPRGP
AELPHWALRD ERFRTLLREA QRQVKQSRQE QRQEEAAERR LRKASKEVLQ MRGQSHKEPL
PVQTFREKMA FFTRPRFNIP PLPADDV
//
