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Database: UniProt
Entry: W5KTZ6_ASTMX
LinkDB: W5KTZ6_ASTMX
Original site: W5KTZ6_ASTMX 
ID   W5KTZ6_ASTMX            Unreviewed;      1176 AA.
AC   W5KTZ6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 29.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a {ECO:0000313|Ensembl:ENSAMXP00000011058};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011058, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000011058, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000011058};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000011058}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; APWO01043717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01043718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01043719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01043720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000011058; ENSAMXP00000011058; ENSAMXG00000010767.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; NITTHEP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     38     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     69     87       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    120    143       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    379    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    410    430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    505    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    580    605       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1091   1112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1124   1142       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    266       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      378    614       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1053   1174       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      263    283       {ECO:0000256|SAM:Coils}.
FT   COILED      601    628       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1176 AA;  133351 MW;  C50F7783EF87B309 CRC64;
     MILATIIANC IVLALEQHLP DGDKTPMSER LDDTEPYFIG IFCFESGIKI LALGFAFHKG
     SYLRNGWNMM DFVVVLTGIL SSVGSQFDLR TLRAVRVLRP LKLVSGIPSL QVVLKSIMKA
     MIPLLQIGLL LFFAILMFAI IGLEFYIGKF HKTCFDEITD EIREEFPCGL EPPSRLCPNG
     TVCRLYWLGP NYGITQFDNI LFAVLTVFQC ITMEGWTDLL YYSNDASGSA WNWMYFIPLI
     IIGSFFMLNL VLGVLSGEFA KERERVENRS EFLKLRRQQQ IERELNGYLE WICKAEEVIL
     ADEDHDGDDR MPFDGSRRRP TIKKSKNDLL NPEEGDGDLT LGSPFARASL KSSKLEGSSF
     HKKERRLRFF IRHIVKTQAF YWTVLCLVGL NTLCVAVVHY DQPDRLSDFL YFAEFIFLGI
     FMSEMCIKIY GLGTRPYFHS SFNCFDCIVI CGSIFEVLWA MIQPGTSFGI SVLRALRLLR
     IFKVTKYWAS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFEGGTPPT
     NFDTFPAAIM TVFQILTGED WNMVMYDGIA SQGGVNKGMV FSIFFIVLTL FGNYTLLNVF
     LAIAVDNLAN AQELTKDEQE EEQAANQKIA LQKAKEVAEV SPLSAANLSI AAVTVHSERL
     NTSEPFLDCK EQQKNQKNHK GSKSVWEQRT SELRRQTLMT SREALYNELD PEDRWKVSYS
     RHIRPDMKTH LDRPLVVDPQ ENRNNNTNKT QPGESQRSGQ ELLHKPPAFH PPGPGRPLER
     GESTESNRSR RDPDNQASTR TSPCGNEGPE GGTREPHRRR TCQSGQSGRS RQHRKTEGGT
     EWEHGDGVER KQRRHRHGDK EGKRERGEQG ERVRHRTRKD GPTLSTTRPI QKTLSRQDSQ
     YSEDLDNVMN SKLATQPLVP SSTRKHSTPH SSLLSLTNST HGTHLGTESS LILTNPTSTT
     TNLANLAHFS NLDKPDYTSI DMPPIFPSHN AILQVNKNAN TEPLPKKEDT KCDDDDDEKD
     DGGPKPMPPY SSMFILSTTN PFRRLCHYVV TLRYFEMCIL LVIAMSSIAL AAEDPVWPDS
     PRNNVLRYFD YVFTGVFTFE MLIKMVDLGL VLHQGSYFRD LWNILDFIVV SGALVAFAFT
     GSSKGKDIST IKSLRVLRVL RPLKTIKRLP KLKVSY
//
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