ID W5KU13_ASTMX Unreviewed; 812 AA.
AC W5KU13;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=SPG7 matrix AAA peptidase subunit, paraplegin {ECO:0000313|Ensembl:ENSAMXP00000011075.2};
GN Name=SPG7 {ECO:0000313|Ensembl:ENSAMXP00000011075.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011075.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011075.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR AlphaFoldDB; W5KU13; -.
DR STRING; 7994.ENSAMXP00000011075; -.
DR MEROPS; M41.006; -.
DR Ensembl; ENSAMXT00000011075.2; ENSAMXP00000011075.2; ENSAMXG00000010787.2.
DR eggNOG; KOG0731; Eukaryota.
DR GeneTree; ENSGT00940000156329; -.
DR HOGENOM; CLU_000688_23_2_1; -.
DR InParanoid; W5KU13; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010787; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF8; PARAPLEGIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..812
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017302839"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 356..496
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 121..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 122..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 90092 MW; 62BFE73CCB720626 CRC64;
MALLLLLLRC GSRSSKYSNV NSIRSGWALS SRSSCSHLRT GKALLDTPIR VSPTCSRCGS
AGLFIQQSRR GLKSGVLQQL LNRPLSAEFQ GLSRAVCRNS LGTNPLGLWK ILGGINYFST
SSRKQDKKDG SKGKTPEEDE EEKRRREQEE QIYRERVRTL VFIAIIMSLL NSINTSGGNI
SWSDFVNEML AKGEVSWVQV VPESEMVEIH LHPGAVIFGR PKLALMYRIQ VANIDKFEEK
LRAAEDQLNI DAKDRIPVSY KRTGFFGNAL YSLGMAAIGV AILWYIFRLA GLGVREGGFG
AFNQWKMAKF TIVDGKSGKG VSFKDVAGMH EAKMEVKEFV DYLKNPERYL QLGAKVPKGS
LLLGPPGCGK TLLAKAVATE AQVPFLAMAG SEFVEVIGGL GAARVRSLFK EARSRAPCIV
YIDEIDAVGK KRSNNMSGFT NTEEEQTLNQ LLVEMDGMGT TDHVIVLAST NRADILDNAL
MRPGRLDRHI FIDLPTLQER KEIFEQHLKI LKLSQPADVY SLRLAELTPG FSGADIANIC
NEAALHAARE GHKSIDTFNF EYAVERVIAG SVKKSKILSK EEQRVVAFHE SGHALVGWLL
EHTEAVMKVS IAPRTNAALG FAQILPKDQY LFTKEQLFER MCMALGGRAS EAITFNKVTT
GAQDDLRKVT RVAYAMVKQY GMVPSVGHVS FPESEVQGPL GRRPFSQGLQ QKMDHEAKML
IAHAYRKTEK LLLDNRDKLA VLANALLERE VVNYEDIEAL LGPPPHGPKK MIAPQSWIEA
EKDKQDTGEE EPRRPQRPPR KDEEEEVNPG PA
//
