ID W5KUC6_ASTMX Unreviewed; 795 AA.
AC W5KUC6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011188.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011188.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; W5KUC6; -.
DR Ensembl; ENSAMXT00000011188.2; ENSAMXP00000011188.2; ENSAMXG00000010900.2.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_0_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010900; Expressed in bone element and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF26; INTEGRIN BETA-5; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..795
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017331425"
FT TRANSMEM 716..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..71
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 30..459
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 631..715
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 739..786
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 81..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 31..41
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 34..70
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 44..59
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 255..296
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 397..409
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 429..678
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 457..461
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 480..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 485..494
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 496..509
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 524..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 526..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 531..544
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 546..551
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 565..570
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 567..598
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 572..581
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 604..609
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 606..654
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 611..621
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 624..627
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 631..640
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 637..710
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 658..686
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 795 AA; 87714 MW; 79B75DD2591DDFF0 CRC64;
VAARFSICCA CVFDGCVLCL NVCMSGSATS CEECLLIHPS CAWCAQEEFG RARTLTSRCD
FSQNLLKRGC EPRFIENPRS VSSTLKNRPL SSKSSGSTQY GVTQIQPQKI SVSLRPGDQT
SFEVQVRPVE DYPVDLYYLM DLSLSMKDDL DTIRNLGTKL AEEMKKLTSN FRLGFGTFVD
KNMSPFSYTA PSYQENPCNG YKPFPNCVPS FGFRNLLSLT DKVDRFNEEV QKQMVSRNRD
APEGGFDAIL QAAVCKEKIG WRKEAYHLLV FATDDVPHLA LDGKLAGLVQ PHDGQCHLND
KNEYSASTKM DYPSLALLGE KLAENNIFLI FAVTKRHYVL YKNFTALIPG TTVEILDQSS
KNIIQLIVNA YNNIRSKVEL SVWDHPEDLS LAFTATCQDG QSLPGLRKCA DLKIGDTVSF
NISVDARGCP PPGTQKSFSI KPVGFKDRLE VSVDYLCGCS CTRYTQNNSS RCSSSGTYTC
GTCRCEPGYR GAHCECEEGD TSSLNLGACR EAEGKQVCSG RGECSCNQCW CYESEFGKIY
GTFCECDDFS CARHKGILCS GHGDCHCGEC KCHAGYIGDN CNCSTETAPC VSEDGRMCSG
RGSCVCGRCQ CTEPGAFGDT CEKCPTCPDA CATKRECIEC RLFNTGKYAD NQTCQRMCKD
QIMSMDTLHT DDPSAVLCLY KTENDCVMKF TYSEHASGQS VLKALQKPEC ASAPDALTVV
MAVVGSILLV GIVLLAIWKL VITIHDRREF ARFQSARSRA RYEMASNPLY KQPISTHPVE
TVFHMHSKSY NGGVH
//
