ID W5KUP0_ASTMX Unreviewed; 890 AA.
AC W5KUP0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2-like {ECO:0000313|Ensembl:ENSAMXP00000011302.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011302.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011302.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR AlphaFoldDB; W5KUP0; -.
DR STRING; 7994.ENSAMXP00000011302; -.
DR Ensembl; ENSAMXT00000011302.2; ENSAMXP00000011302.2; ENSAMXG00000010798.2.
DR eggNOG; KOG1055; Eukaryota.
DR GeneTree; ENSGT00940000155783; -.
DR HOGENOM; CLU_005240_0_0_1; -.
DR InParanoid; W5KUP0; -.
DR OrthoDB; 3984905at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010798; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..890
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017363004"
FT TRANSMEM 452..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..736
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT COILED 778..805
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 890 AA; 100786 MW; D52ED39CD8DCB026 CRC64;
MDDCWTLLKV LMMWELLYFP WLGLCQRREQ LPVLWIMPLS SEPAWGNVTA EVMPAVQLAL
QHLSKQPAPL RNYELQFHFA DSKCDNARAL KGFFEAIFYG PKYLTVFGGL CSSATSTIAQ
SLQAFNLPQL SFAATAPAFA NKSRYPNFFR VVPSDSAVNP ALLKLLSYYG WRRVGTLTQQ
EERFTEVQKD LTEILNEVGV ELAEAQWFFG DPCSAVKTLK ENDVRIVIGQ FDEFSAAKVF
CCVYQLGMFG HKYQWILSGW SQTSWWTHTG TSNCSAQSIL NAMEGTVSVD FETLSSRHTR
GVSGRTPQEY KREYERRCML KGLGSSKFHG FAYDGTWVLA KALTEVMEML KYREKYSIHR
NLTITDREVT HMILQALGDT KFFGVTGHVL FRNGERVANI KFAQFQAGKE VQVGEYSAIT
DRLVFASPIW FKGHEYTRDH THIYPQRMEI NIILYSILAS ISALGILMSI ACLFFIILNH
GHRSVQISSP SLNTLLILGT LLSYSSVFLF GLDGSYVSEG VFDALCSVRI WFITIGYTTA
FGTMFAKIWR VYSMFNHISA QKRIIKDHVL FRIVCGLLLV DVCFLIILQV LDPLRRLVEE
FSLEADPDGR DFAIRPFLEH CENSYMNIWM AFMYLSKSWL VLLSCVLAWK THPPNTLVLS
DCRWTRISVC LTGPLSVIGA CVGLLTRDQP NVQFCVLGIV IITCCSVTLS LTFVPKLILM
RTNPDGASLP EQFHTTETEK ERECVSEVKE RMKQRESSAS SCLKLIITSP LEVLQSDNQH
LTRHIIELNW ELEELARQLR ELSALSYRSI ISMQESGELT GTEKCQTLPT GYSGKDLEDI
NSPEQVQRRL SLQLPILHHA YLLSIGGVNA SCSTPSSPSA QHKALMGLWH
//
