ID W5KW81_ASTMX Unreviewed; 707 AA.
AC W5KW81;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Nitric oxide synthase 1 (neuronal) adaptor protein a {ECO:0000313|Ensembl:ENSAMXP00000011843.2};
GN Name=NOS1AP {ECO:0000313|Ensembl:ENSAMXP00000011843.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011843.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011843.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KW81; -.
DR STRING; 7994.ENSAMXP00000011843; -.
DR Ensembl; ENSAMXT00000011843.2; ENSAMXP00000011843.2; ENSAMXG00000011523.2.
DR eggNOG; KOG4458; Eukaryota.
DR eggNOG; KOG4815; Eukaryota.
DR GeneTree; ENSGT00510000046975; -.
DR HOGENOM; CLU_026008_0_0_1; -.
DR InParanoid; W5KW81; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011523; Expressed in intestine and 14 other cell types or tissues.
DR CDD; cd01270; PTB_CAPON-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027851; DUF4628.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR11232:SF76; CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN; 1.
DR PANTHER; PTHR11232; PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER; 1.
DR Pfam; PF15429; DUF4628; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 29..165
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 172..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 77609 MW; 09DE961315264B9F CRC64;
MPAKTKYNLV DDGHDLRIPL HNEEAFQHGI NFEAKYIGSL DVARPNSRVE IVAAMRRIRY
EFKVKNIKKK KVNIMVSVDG VKVVLRKKKK KKEWTWDESK MMVMQDPIYR IFYVSHDSQD
LKIFSYIARD GQSNVFRCNV FKSKKKSQAM RIVRTVGQAF EVCHKLSLQH TQQNADGQED
GDSQKTCTDS GVQDRELTGA EKTAAEETDI DAEELPLPDS TVDEFSRGVT DLDAAKKEDD
VTIDKNLSED ASILLASPKM LLPSGSQLPA GTPLSSHHQL QLLQQQLTQQ QQQTHVAVAQ
VHLLKDQLSA EAAARIEAQA RVHQLLLQNK DLLQHISLLV KQVQELELKM AGHGSMGSQD
SLLEITFRAN VPPVICDPTT PRPEDSIFPP LNDGTQLSLP LGSPLVDQSM FENSNAAEQQ
KQSLRMAGVV SSSPAGQKSG GSSSQHLKNL GKAVGAKVND LLRRKDPSSL GDIGVTEVNK
NVEAVWASLT EMGLGTTANS HMSLDSFPRL DPPPPTSKKR LPRALKTTQD MMISSDPVVA
SPEVSDSSLL SSPDKSCLIS SSKAQDQFQP CLEEPGLEPE TPSAASTPLE IQIKEESGSA
EVKGQCGSTD AVQMADGLKE LDAAKEDQSQ VLRSVPDLIH KDNLELKQKL NSMESRMAST
PCPGKGGCRI SLSEGELLEN GSVDYKSSRR SSNMENEEPH PDLLSFE
//
