ID W5KWA9_ASTMX Unreviewed; 1249 AA.
AC W5KWA9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ski2 like RNA helicase {ECO:0000313|Ensembl:ENSAMXP00000011871.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011871.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011871.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5KWA9; -.
DR STRING; 7994.ENSAMXP00000011871; -.
DR Ensembl; ENSAMXT00000011871.2; ENSAMXP00000011871.2; ENSAMXG00000011517.2.
DR eggNOG; KOG0947; Eukaryota.
DR GeneTree; ENSGT00940000158255; -.
DR HOGENOM; CLU_002902_1_4_1; -.
DR InParanoid; W5KWA9; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011517; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 328..484
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 599..764
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 232..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 140613 MW; 5068E43818E3F3CA CRC64;
MDKLELPPPG PDDLPLSLLE MGCSGRFELL THSLPSNKPI QPQNTLPHGL PPTNVDLKME
VEKRFLQDPA WMPIHDTTDA FQKFLKLTKR DRQVDSLLHC SLSPLHSSLS VVRDPTTGML
LDFTEVLLEH TGLSAKNSFS LQRQPGPPAE SLRGSNTNYP FLPGGMEELT LEQIKKKSEL
EEDIDFEHDL LAVPPGLKTG MDFSDKEAKT TKGEVNLLSL LSTFDDIIDQ MPEEKDKDKK
SGESSKLSRT NSLEDLGIKD TQSSFTPPKT SQADKTAEMK KKETEAKKER KWAVPVDISC
PCDDFYKRIP DPAFKYPFEL DTFQKQAILR LEVHDSVFVA AHTSAGKTVV AEYAIALSQK
HMTRTIYTSP IKALSNQKFR DFKNTFGDVG LLTGDVQLNP EASCLIMTTE ILRSMLYNGS
EVIRDLEWVI FDEVHYINDA ERGVVWEEVL IMLPEHVSII LLSATVPNAV EFSEWIGRIK
KKPIYVISTV KRPVPLEHYL YTGNSTKTQK ELFLLLEATG SFLTKGYYAA VEAKKERTSK
HAQSFGAKNA AHNTTLSQDR AIWQTLLNYL SQRQQTPVVA FTFSRTRCDD NSRSLNSLDL
TSSVEKNEIH SFFHKSLSRL RGGDRQLPQI LVMRDLLKRG IGVHHSGILP ILKEVIEMLF
SRGLVKVLFA TETFAMGVNM PARTVVFDSI RKHDGTGFRN LLPGEYIQMA GRAGRRGLDA
TGTVIILCKS GVHDMGDLHA MMLGKPTVLQ SQFRLTYTMI LNLLRVEALR VTDMMRRSFS
ENHRDTQTHE KRISELRTLL SSLPPLDTEG QLSDLLQYYH TVNELRLTTE ALQQAVMESM
NGLKALSVGR VVVVNNAQHF NALAVILQVS NDSVNRMFTA LIICEKGNEE TSETTQLNRG
FRHLHNTSLF IPEGPCSHTV QKLKAQDISA ITVKTLKVIP ERIIDNYNKR QQPRFRMDPP
GQAISTATQE LLRLAEANPD GITSLDPVND LHLKGVDVVE GVMRQRVIQD CLKDFQCTHS
PTFNEQFARV QERMGLQEEL DRLLFLVSDM SLTLLPEYNQ RIKVLKELKY IDESDAVQLK
GRVACQISSH ELLLTELLFE NTLSPLAPEE SAALLSCLVF TQNTQIEPHI PNTIQEGIDR
VLCVAQRIGE LQRECGIAQT AEDYVSQFKF GLTEVVYCWA RGMPFAEIAM LTDVQEGTVV
RCIQRLDEVL KEVRQAARIV GDSVLGSKME RASLAIRRDI VFTASLYTH
//