ID W5KWI3_ASTMX Unreviewed; 416 AA.
AC W5KWI3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Testin {ECO:0000256|ARBA:ARBA00019588};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011945.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000011945.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000256|ARBA:ARBA00008268}.
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DR AlphaFoldDB; W5KWI3; -.
DR Ensembl; ENSAMXT00000011945.2; ENSAMXP00000011945.2; ENSAMXG00000011622.2.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00940000155993; -.
DR HOGENOM; CLU_008937_1_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011622; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09413; LIM1_Testin; 1.
DR CDD; cd09416; LIM2_Testin; 1.
DR CDD; cd09419; LIM3_Testin; 1.
DR CDD; cd09829; PET_testin; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR034958; LIM1_Testin.
DR InterPro; IPR034959; LIM2_Testin.
DR InterPro; IPR034960; LIM3_Testin.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033724; PET_testin.
DR InterPro; IPR047120; Pk/Esn/Tes.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24211:SF1; TESTIN; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 93..200
FT /note="PET"
FT /evidence="ECO:0000259|PROSITE:PS51303"
FT DOMAIN 227..290
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 292..352
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 416 AA; 46499 MW; 37C57CE5CB7E1389 CRC64;
MEIEKEVKKI TLGHEVGAGA ACLKCKDKCE GFELHFWRKI CRNCKCGIED HDVQLQTEES
QKVGRLFEDT KYTGLIAKLK KDGVPSYRSN QVTISVTAPA IAKTNVVKAI TYDWAPPGVN
QSLALRYMEL LPPEQRPIAG TQGAGYRKKQ MAKQLPEHDQ DPTRCHELSP AEVKQMEQYI
RKYKDEALGM GDLTLPEEMV TLAESAGALG PQALEAGAAG DKAAVGKVCH HCQKVMQQGD
PAVYAERAGY DKLWHPACFV CCTCKELLVD MIYFFKKGQL YCGRHYGDSE KPRCGGCDEL
IFSNEYTQAE GQNWHLKHFC CFDCDCVLAG EIYVMENDKP VCEPCYMKNH AVRCAACLKP
IEPEAQRVSY GEHHWHADPQ CFLCSGCSKC LMGQRFMALQ GKLLCSVECK KKVLAS
//
