ID W5KWU4_ASTMX Unreviewed; 890 AA.
AC W5KWU4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=PHD finger protein 14 {ECO:0000313|Ensembl:ENSAMXP00000012056.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012056.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012056.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KWU4; -.
DR Ensembl; ENSAMXT00000012056.2; ENSAMXP00000012056.2; ENSAMXG00000011710.2.
DR eggNOG; KOG0957; Eukaryota.
DR GeneTree; ENSGT00940000156923; -.
DR HOGENOM; CLU_006506_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011710; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15674; ePHD_PHF14; 1.
DR CDD; cd15561; PHD1_PHF14; 1.
DR CDD; cd15562; PHD2_PHF14; 1.
DR CDD; cd15563; PHD3_PHF14; 1.
DR Gene3D; 2.30.30.1150; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF150; PHD FINGER PROTEIN 14; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 4.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 3.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 263..324
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 326..443
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 670..724
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 813..866
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 22..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 574..601
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 52..71
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 890 AA; 99293 MW; 492A18BE1E83BF34 CRC64;
VDRTSKRRQV KPLAASLLDV LDYDSSDDSD FEVGDADASG NLAAGTDSDS DAIGSADEEG
VDDDETKEIN EDVQEEEKTK EQPSSEETSS KETGGTSRSR RKSEKPPDPE PNGSGTAEEN
PAEPKKWNLR RNRPMLDFTT MEHELNAMDD YDSEDDNDWR PSAEKKKSKD GGSDDDDDID
DDDDDDDDDD DDNEEGDDDD DNDSSSDGDA VVKKSKKSKS NKSSGAFDEE ETNDSHSTSH
GKGNEDSLLE RTQPWSAQRM EHILICCVCL GDNSEDADEI IQCDNCGVTV HEGCYGVDGE
SDSIMSSASE NSTEPWFCDA CKNGVTPSCE LCPNQDGIFK ETDAGRWVHV VCALYVPGVA
FGDIDKLRPV TLTEMNYTKY GAKECSLCED ARFARTGVCI SCDAGMCRSY FHVTCAQREG
LLSEAAAEED IADPFFAYCK QHADRFDRKW KRKNYLALQS YCKVSLHERE RQLTPEAQAR
ITTRLQQYRT KAELSRNTRP QAWVPREKLP RPLTSSASAI RKLMRKAELM GISTDIFPVD
TSDTSASIDG RRKHKQPALT ADFVNYYLER NMRMIQIQDN ISEQKNLKDK LESEQEKLHV
EYNKLCESLE DLQNVNGLLR TEGQAMWSVM GGILGQKLNG PAILKAPKER KPSKKEGGSP
GKSSSLPAVL YSCGICKKNQ DQHLLLLCDT CKLHYHLGCL DPPLTRMPKK TKNSYWQCSE
CDQASSDEAD IAMETLPDGT KRSRRQIKGP IKFIPQEMSP EPKKPQVRGT RTRGQKRKRV
SICEEEKIEE PAPRERRQRQ SALQKKPKAD DTRTECTTCK GPGDNENLVR CDECRLCYHF
GCLDPPLKKS PKQTGYGWIC QECDTSSSKV SAAEPAVETR PPGPASAPIT
//
