ID W5KWY8_ASTMX Unreviewed; 350 AA.
AC W5KWY8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=N-terminal EF-hand calcium binding protein 1 {ECO:0000313|Ensembl:ENSAMXP00000012100.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012100.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012100.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KWY8; -.
DR Ensembl; ENSAMXT00000012100.2; ENSAMXP00000012100.2; ENSAMXG00000011773.2.
DR eggNOG; ENOG502QWRY; Eukaryota.
DR GeneTree; ENSGT00950000183131; -.
DR HOGENOM; CLU_041553_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011773; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR007138; ABM_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039862; NECAB1/2/3.
DR PANTHER; PTHR12178; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12178:SF11; N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1; 1.
DR Pfam; PF03992; ABM; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51725; ABM; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 32..59
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 250..338
FT /note="ABM"
FT /evidence="ECO:0000259|PROSITE:PS51725"
FT COILED 209..239
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 350 AA; 40913 MW; 2B8A29194AEEB1DE CRC64;
MPRGRVSTVG AHVTVFSYRE RWWMKKHAHT LILRRADKND DGKLSFDEFK AYFSDGVLTG
DELKELFHTI DTHNTDNVDT DELCEYFSQH LGEYENVLAA LEDLNVSILK AMDKTKKEYQ
EATHLEQFVT RFLLKETTSQ LQSLQSSLEC AMETTAEQTR QERQGPVKPE VLSIQWSGRR
SNRRLQRNNS LSPNNPLLSL VNSGLYEEDN QWMTQINRLQ KLIDRLEKKE LRLEPVEEEV
SEGTTKSHIL IVQRQLPVLE DELEEFRLAL RQYIDCASAQ TGCLHVAVQR MANESRFILY
EFWEHSNVWK NHLQTNYSKT FQRGNVDFLE TPEITTTMLV PASWWVLNNN
//
