ID W5KXN8_ASTMX Unreviewed; 1420 AA.
AC W5KXN8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Roundabout, axon guidance receptor, homolog 2 (Drosophila) {ECO:0000313|Ensembl:ENSAMXP00000012350.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012350.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012350.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000012350.2; ENSAMXP00000012350.2; ENSAMXG00000011947.2.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000156324; -.
DR HOGENOM; CLU_003227_5_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011947; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF52; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1420
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017329124"
FT TRANSMEM 870..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..312
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..416
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 425..505
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 532..626
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 645..743
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 747..844
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 613..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1294
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 154730 MW; D6224AC64F6F73F6 CRC64;
MGPLAWFFIF ICGLIHFQAD GSRLRQEDSP PRIVEHPSDL IVSKGEPATL NCKAEGRPTP
TVEWYKDGER VETDKDDSRS HRMLLPSGSL FFLRIVHGRR SKPDEGAYVC VARNYLGEAV
SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECVPPRGH PEPTIFWKKD KVRIDEKEDR
IKIRGGKLMI SNTRKSDAGM YVCVGTNMVG ERDSETAQVT VFERPTFLRR PINQVVLEDE
AVEFRCQVQG DPQPSVRWRK DDVDVARGRY DIRYDKDDYV LRIKKASAGD EGTFTCVAEN
RVGKLEASAT LTVRARPVAP PQFVIRPRDQ IVAQGRTATF PCETKGNPQP AVFWQKEGSQ
NLLFPNQPQQ PNSRFSVSPS GDLTITGVQR ADAGYYICQA LTVAGSILAK AQLEVTDVLT
DRPPPIIRQG PANQTLGVDG VALLKCQASG EPVPTISWRK DGVSLLGKDP RMSLLDLGSL
QIKNIRLSDS GIYTCVAASS SGETSWSAFL EVKESAGVVT IKNRDESELP GPPSKPQVTD
VTKNSVSLSW QPGLTGASVT TSYVIEAFSQ SVSNSWQTVA DHVKTTQYTI KSLRPNTIYL
FMVRAVNAQG LSDPSPMSEP VRTQDISPPA QGVDHRHVQK ELGEVIVRLH NPVVLSPTTI
QVTWTVDRQS QFIQGYRVVY RQTSGLSSPG PWQSQDVKVP SERTVVLSSL KKGIVYEFKV
RPYFNEFQGM DSESRTARTT EEPPSAPPQQ VTVLTVGNQN STSISISWDP PPADHQNGII
QEYKIWCLGN ESRFHVNKTV DAAIRSVVVG GLQAGVLYRV EVAASTSAGV GVKSEPQPIV
IGKDFRDVIV SGNKNNSITE QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL
SNYAVQSFTF TPAVTFQRVD GGLMSNGSRP GLLSAGDAGY PWLADSWPAT SMPVNSSSAG
PNDLSNFSGR GDVMPTAQPD KTGTMLSDGA IYSSIDFTTK AGFSSPSPAS QATPYATTQI
LHSSSIHELA VDLPDAQWKT SLQAKQEMAN LGYSLPDKNS CNNTLLFIPD YRLADGLSNR
MPHNQSQDFS TTSSHNSSER SSSLSGGKGG KKKKTKAGAK PTKANGSNWA NVPLPPPPIH
PLPGTELDHY PTEHHEGGGY ESDGWGPPLP VQTYLHQGLE DELEEEEERV PTPPIRGVAS
SPAAVSFGKQ STATLTPSPR EEIQPMLQAH LDELTRAYQL DMAKQAWHLQ GGTYPPQAPA
PPVGYMSSTL VSDIETDLPD DDDDDEDDQE EDEGYEMSPP LRGIEHTPGS SMDNLDSSVT
DKALGARPRP ASPFSTDGST MGTHSLGHQR AARPTRKHRG PGTAPHRRDA SADEEVMPPY
SKPSFPSPGG HSSSGTTSSK GSTGPRERRG VTRSAPARQH
//
