GenomeNet

Database: UniProt
Entry: W5KY02_ASTMX
LinkDB: W5KY02_ASTMX
Original site: W5KY02_ASTMX 
ID   W5KY02_ASTMX            Unreviewed;      2011 AA.
AC   W5KY02;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 32.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012464, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000012464, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000012464};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000012464}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; APWO01113510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01113511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01113512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000012464; ENSAMXP00000012464; ENSAMXG00000012098.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     97    116       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    123    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    709    727       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    739    757       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    819    847       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    907    932       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    952    970       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1245   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1273   1292       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1337   1357       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1444   1467       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1528   1546       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1558   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1644   1672       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1748   1771       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      498    616       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      709    937       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      946   1200       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1204   1476       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1527   1781       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      438    458       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2011 AA;  229196 MW;  107A247B84BED64E CRC64;
     MATMLLPAGP DALRRFTRES LVAIEQRIAD EQAKNAKDTP PNKGTTEEPK LDLEAGKVLP
     RIFGDIPTGL VGVPLEDIDP FYFKNKKTFI VLNKGKAIFR FSATSAVYIF TPFHLIRRIS
     IRILLSTLFS FFIMCTILTN CCFMAMSDPA HWTKYLEYTF TGIYTFESLI KILARGFCLE
     PFTFLRDPWN WLDFSVIVMA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI
     QSVRKLADVM ILTVFCLSVF ALIGLQLFMG VLRQKCVRSA AHCVNSTFPA NTSFVCNNKT
     WQSMKEFVTS EENYYKIEGA KDGLICGFSS DAGKCPDGFD CLKTGRNPNY GYTSFDSFGW
     AFLALFRLMT QDYWENLYHQ TLRSAGKTYM IFFVLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAEAWQK EREFQLAMEQ LRRDQRALAK RNKEAELARA QELLPSPIKR RDSRDRRARS
     RSHRTMSEET EEDTDLRSPK FDPFEEKPAH PLLATLSSHP LSSRRGSNIS IFTFRPRNNS
     EADFADDETS VIGDHGSRSR AGSTVTPWHK RRTGSVRSHC SQVFTPTLTV NGRLNLSLEQ
     NGITGITLHT PTSFPGCSME KVKEDTELVC ATEAPKPVPE VQVEAPPPRR KRGLSSISFF
     SDAMDELEES RQKCPPCWYE FAKKYLIWTC APVWMKFKDG VKIMVMDPFL DLAITICIVL
     NTLFMALEHY PMTEEFNGML SVGNLVFTGI FTAEMVLKLV AMDPYFYFQQ GWNIFDGIIV
     CLSLMELGLS NVEGLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL GNLTLVLAII
     VFIFAVVGMQ LFGKNYQDCV CKISIDCSLP RWHMKDFFHS FLIVFRVLCG EWIETMWDCM
     EVAGQPLCIL VFMLVMVIGN LVVLNLFLAL LLSSFSSDNL SAPDDDGEMN NLQIAIARIH
     SGLTWLLAFI KDLCSGNLTK RNQKNKEGQG AKKCQNSNHA ECNGVVGRIG RYGEKYIITE
     EEDSYMTNPN LTICVPIAPG ESDVEFLEEE EEEDTETSED EDNKPIRAEM RNASAQVDQL
     AKEGPKKEHQ YKLFMPFITL MDYIYVSNIH GSLFFSISPN VVWHHMVYQT SLEVVSLSEG
     STVDLRKPGE EDEMSELIED TMEPEECFPE FCVRRCECCK INTTQGLGQA WWRLRKTCYQ
     IVEHSWFETF IIFMILLSSG ALAFEDIYIE QRKVVKVVLE YADKVFTYIF VLEMFLKWIA
     YGFKKYFTNY WCWLDFLIVD VSLISLVANS LGYSDFGAIK SLRTLRALRP LRALSRFEGM
     RVVVNALIGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GKCVNRTGYI HNASIVNNKS
     DCQSMNDTQF YWTKVKVNFD NVGLGYLSLL QVATFKGWME IMYAAVDSRG VEEQPIKEIN
     LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKRKLLQG GQDIFMTEEQ KKYYNAMKKL
     GTKKPQKPIP RPANILQAFI FDLVSKQAFD ISIMMLIILN MITMMIETDE QSDRMESILN
     KVNLAFIIIF TTECLFKIFA LRCYFFTISW NVFDFVVVIL SIIGIVLADI IEYFVSPTLF
     RVIRLARIGR VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMANFAYV
     KKQGGIDDMF NFETFGNSMI CLFQITTSAG WDNLLDPILN NSPEECNPNI VNTGTNTKGN
     CGNPSVGITF FVSYIIISFL IVVNMYIAII LENFSVATEE STEPLSEDDF EMFYEVWEKF
     DVEATHFIEY SMLSNFADAL SEPLRIAKPN KIKLISMDLP MVSGDKIHCL DILFAFTKRV
     LGESGEMDAL KQQMEDKFML TNPSKISHEP ITTTLRRKQE DVSATVIQRA YRRHLVKRQM
     KQASYLYRQI KQEGADVEGT PERVGLIACM IKENYGPEEE VVEESLHSFP PSYETITKAP
     SEHFLIMLPD SRVPAPFETF TSAETYEETF L
//
DBGET integrated database retrieval system