ID W5KYD5_ASTMX Unreviewed; 2152 AA.
AC W5KYD5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Bromodomain and WD repeat-containing protein 3 {ECO:0000313|Ensembl:ENSAMXP00000012597.2};
GN Name=BRWD1 {ECO:0000313|Ensembl:ENSAMXP00000012597.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012597.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012597.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000012597; -.
DR Ensembl; ENSAMXT00000012597.2; ENSAMXP00000012597.2; ENSAMXG00000012221.2.
DR eggNOG; KOG0644; Eukaryota.
DR GeneTree; ENSGT00950000183107; -.
DR HOGENOM; CLU_001108_0_1_1; -.
DR InParanoid; W5KYD5; -.
DR OrthoDB; 24713at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012221; Expressed in zone of skin and 14 other cell types or tissues.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.30.30.1040; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 178..219
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 220..261
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 262..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 360..401
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 462..504
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1188..1258
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1338..1408
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 776..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..2152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..840
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..905
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1598..1612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1632..1665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1691..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1724..1740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1783..1816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1846..1860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1871..1885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1934..1974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2079..2105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2115..2131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2152 AA; 243307 MW; 6E4F9EE2776B74B0 CRC64;
MDRSGSVSSL ESELYFLISR FLTTGPCRRA AEVLVRELEE HQLLPRRLDW EGNEHPRSYE
DLIAANRHIA PDHLLQICKQ IGPILDKDMP SGVPGARSLL GVGRHSLLGK AKDCSTRVWK
GSSFAALHRG RPPERPVCCT DAPNLVEVCR GRELTGAQRF SFVHPVSNYQ HMKMHRRILG
HLSAVYCIAF DRTGSRIFTG SDDALVKIWS SYDGRLHSTL RGHHAEISDL AVNLENTLIA
AGSCDKTIRV WCLRTCAPVA VLQGHSGSIT SLQFSPFVKG SKRYMVSTGT DATVYFWQWD
VNNTSFSDRP QKFTERPRPG VQMVCSSFSP GGMFLATGST DDIIRIYYLG SGSPEKMAEL
NSHTDKVDSI QFCNIGERFV SGSRDGTARI WQLHQRHQWR SILLDMSATL PGSVPASEEE
CFFKPKVTMV SWDRHDSTVI TAVNNHHLKV WNSYTGQLLH VLKGHEAEVF VLEPHPYDPR
VMLSAGHDGN VFIWDLVKGT KTQHYFNMIE GQGHGAVFDC KFTPDGHRFA CTDSHGHLVI
FGFGSSKPYE KLPDQVFFHT DYRPLIRDSN GFVLDEQTQQ APHLMPPPFL VDVDGNPHPP
KYQRLVPGRE NFSDEHLVPQ LGYVATSDGE VVEQVISQQP AESEEPQVRR SILDDAIRQL
QEQQDRRAGG QAVAALVGAP GTPRRVSLSE RMEVQSPPNV GLRRSGQVEG VRQMHQNAPR
SQMATERDLQ AWRRRVVVPE LTFSSYRSQE SYRIAKGEEE IAVYSTKKRR IIQGTFKDDS
DDDGVCTKQA QSRKRQKHLV SKDGVRDYIE FSCEEGEETA SSEDNEMEGS EMDSSNEEEE
EWRSDSSSRS SSECSDWTAD AGITVQPALS SRRRARRQIS SSEDEDEDEE EEEEEHDDDD
EGDNMVEEKQ KEQSRSKEAE SSPQKLKNKM KSKMPKNPKP RPSVNRELSS EFRPSPWITD
VVPRKSPFVP QMGDEVIYFR QGHEAYLEAV CKSNLYPINL DKQPWRKMQL RDQEFVQITG
IKYEVCPPTL CTLKLTQIDP GTGQITDQSF SVKYHDMPDV IDFLVLRQSY DEARNRVWRP
NDRFRSVIDD AWWFGTIVCQ EPYQPEYPDS LFQSFKVKWD NGETEKLSPW DIEAIPENAL
QPESVGAGVP VTDEEMNDIL YKPREGEWGV RSREEESMRI IAGIDQLITV DIAAPFSGPV
DLTQYPAYCT VIAYPTDLGT IRMRLKHSFY RRLSALIWDT KYIFLNARTF NEPRSKIAQS
AKLITDVLLK FISKPHCTDI MDIYNAVENM EYTEDEDLDE GDAPGTSAGQ TSQQTLVEVL
PDRDAWKDAC KRLLDYMFQC EDSEPFRQPV DENEYPDYTN IIDTPMDLET VWRTLDEDRY
ENPTDLCKDT RLIFANAKAF TPNKRSKIYS MTLRLSALFE ERIRKIISDY KTAVKNCSRL
RRSQRFRKRL QQQDPAVSLL KLESTGQKRA AVKTQEQVEL PATKSTSAKV SAPERSSRRR
RKQHSSAYKS TDEYSGASNK SSSESSDASF SGMDEDKGSL SSSSQFRRET RATKRAIQKE
GLKRKQVTAQ KQLNRSERDS SEDDGSEDSE KSSSLKQLKS SRGKSGSTRL TRNSATDRRK
PDCSGQVNGL SRSRVERRRV QHSSGSEEDS SNRDKGSELC TGRRQRKTAK AAVSKMKLIH
ASEEDEGSEQ ENQANSSNWQ TPHTNRRAAV IQSSSGSDEA SKNSEDSASN EEKSEASADS
DFSFSHHNGE SKGAGHRSSR RTVLEEDDSP LVNGYSLDNG RKRLNESQGD VKDEEPPEPE
NHPHQNGQKM DTQDLKYAEK ISNMTFKSHE KASASKARAI PAVTAFKSEQ LSNVPKGASA
SRKRTKSEDG TGGENASSSA EEIPIKKTSL KSKNKLTRSS SSGSESEALN WRRKKKDKKA
VSSDDWQQSD ESENYNEFNR RRPTLRALPK KKYITDSEDD VCLEAEDQHR NGRSSVVSGK
DGGKQLPGGC FKSKRKRIRS SDSEDKEEEK GTISDESECE KPIRRQKRPK QFKPESKESE
SDSVSRRKTE NGLSRKQKGV LSEEFCKNSN RGGKRRLKSS SDSGTSCDSP EESSEESISG
SQSSPKRRLR NRKQAARHSD VESDVSYGKP QRTRKIRTRN LGKRTVCYQD SE
//
