ID W5KYM6_ASTMX Unreviewed; 510 AA.
AC W5KYM6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp31 {ECO:0000256|ARBA:ARBA00013538};
DE AltName: Full=Pre-mRNA-processing factor 31 {ECO:0000256|ARBA:ARBA00030766};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012688.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012688.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PRP31 family.
CC {ECO:0000256|ARBA:ARBA00005572}.
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DR AlphaFoldDB; W5KYM6; -.
DR STRING; 7994.ENSAMXP00000012688; -.
DR Ensembl; ENSAMXT00000012688.2; ENSAMXP00000012688.2; ENSAMXG00000012329.2.
DR eggNOG; KOG2574; Eukaryota.
DR GeneTree; ENSGT00550000075069; -.
DR HOGENOM; CLU_026337_2_0_1; -.
DR InParanoid; W5KYM6; -.
DR OrthoDB; 4493115at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012329; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:InterPro.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR InterPro; IPR027105; Prp31.
DR InterPro; IPR019175; Prp31_C.
DR PANTHER; PTHR13904; PRE-MRNA SPLICING FACTOR PRP31; 1.
DR PANTHER; PTHR13904:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF09785; Prp31_C; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 228..346
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..36
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 56492 MW; A9FB253692247FBB CRC64;
MSLADELLAD LEEAGDEGED GLYPGGEGEE SDGEDRERED NGGLEDIPEE MELDYSGAES
VSSIAKLRNS KSFSEIMEKI SQYVGNPRNN TDVSGPVEAD PEYRLIVAAN NLTVEIDNEL
NIIHKFVRDK YSKRFPELES LVPSSLDYIR TVKELGNNLE KCKNNETLQQ ILTNATIMVV
SVTASTTQGT LLGEEELQRL EEACDMALEL NQSKHRIYEY VESRMSFIAP NLSIIVGAST
AAKLMGIAGG LTNLSKMPAC NLMLLGAQRR TLSGFSSTSL LPHTGYIYHC DVVQSLPPDL
RRKAARLVSA KCTLASRVDS FHESADGKVG YDLKEEIERK FDKWQEPPPV KQVKPLPAPL
DASRKKRGGR RYRKMKERLG LTEIRKHANR MTFAEIEDDA YQEDLGFSLG QLGKSGSGRV
RQAQVNDATK ARISKSLQRT LQKQSMTYGG KSTVRDRSSG TSSSVAFTPL QGLEIVNPQA
AEKKVAEANQ KYFSNMAEFL KVKKEGNDKS
//
