ID W5KYV7_ASTMX Unreviewed; 357 AA.
AC W5KYV7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=GRAM domain-containing protein {ECO:0000259|SMART:SM00568};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012769.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012769.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KYV7; -.
DR Ensembl; ENSAMXT00000012769.2; ENSAMXP00000012769.2; ENSAMXG00000012429.2.
DR eggNOG; KOG1032; Eukaryota.
DR GeneTree; ENSGT00940000165115; -.
DR HOGENOM; CLU_1032572_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012429; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46645:SF1; GRAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46645; GRAM DOMAIN-CONTAINING PROTEIN 2B-RELATED; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..157
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 249..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39736 MW; 73238EB7237D8BE1 CRC64;
MNGDKQLNRR FSLDSLGYSP DCGGLLGKAK GCKMRRSIDC TKSRGLDEAH LELDINRNLN
GTSPAKNSTI EEEGDRIDGL SRNSFKNHKK TFHKHFPEIA ELEELTSAFT CAIQKEVLYH
GRMYISEHHV CFHSSVLLKE TKVVIPASTI QVIKKKNTAR VVPNAISIIT NNTEKHLFVS
IRNRDVCFKL LQLICPHLQT GSANGSPQMS SVENVHELEI DTISSHSSQE DNGDHRRVSL
PERDKIPLSS FSVSDIPNGQ AKNGSTSQSE PSRTEGHSTE EIQKDTETVS WVTMVTEKIR
SAVSTRTTSQ LNKLLTVYLL LVLLLLLTSG YIGLRIVALE EQLNTLGSLP EFSLQTE
//
