ID W5KZH4_ASTMX Unreviewed; 700 AA.
AC W5KZH4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|ARBA:ARBA00013194};
DE EC=5.2.1.8 {ECO:0000256|ARBA:ARBA00013194};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012986.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012986.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971};
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DR AlphaFoldDB; W5KZH4; -.
DR STRING; 7994.ENSAMXP00000012986; -.
DR Ensembl; ENSAMXT00000012986.2; ENSAMXP00000012986.2; ENSAMXG00000012632.2.
DR eggNOG; KOG0546; Eukaryota.
DR GeneTree; ENSGT00940000157954; -.
DR HOGENOM; CLU_012062_33_2_1; -.
DR InParanoid; W5KZH4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012632; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110}.
FT DOMAIN 11..176
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 180..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..241
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..351
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..456
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 81814 MW; C202A5F5BA0A04F9 CRC64;
MGVKPQRPRC FFDIGISNTL AGRVVIELFA DVCPKTCENF RCLCTGERGV GKTTQKPLHY
KGCLFHRIVK DFMIQGGDFS EGNGRGGESI YGGFFEDESF SVKHNKEFLL SMANRGKDTN
GSQFFITTKP TPHLDGIHVV FGQVISGQDV IQVIESQKTD ANSRPYAEVK VLNCGELIPK
SKGKEKKKKK QQSSSESSDS SASSSDSSSE SEELDKEDKK QKKKHKKEQK KKKKEQKHKK
KKEKSSDHEE AEEAEPQQPL STIRPEEVPP IPENRFLMRR SPQQQPPKEE EEKEKLKDGS
EKERQREKER ERERERDGPV VNSRQNRTRL VMTRSGRRIK GRGPRRYRTP SRSRSRSWDR
FRRSETPPHW RQEMQRTQKA KPNTQATQDR WIKGDKGDMS EDKADAAESK EKEKPNTDRE
KKNSEREKKE SKRNKSRSPS KGRERKSGRH RSKSRERDGR KKADGETDKR RGRSRSKSKE
RKGEREHKRS KTDEKRDRSS SKDRKEKDKD EKEKQRGEDG KKHRESDKER EKSRSRERER
DRDAKRKSKS KSRSRSRGRG QRGSRERGRD KRQSSSSRDR KSRKSKSRER ESGRERQRET
KDGNEDRNTR GRDRNSKEQS SHKRGSKDGT DQHGGDKERR RRRSSSKSSD SDSDRDKRKK
RTRSESPKSR KKNSEKSRSP RRDRNHHRNQ KKDSSSSDSE
//
