ID W5L1T1_ASTMX Unreviewed; 664 AA.
AC W5L1T1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Rhophilin Rho GTPase binding protein 1 {ECO:0000313|Ensembl:ENSAMXP00000013793.1};
GN Name=RHPN1 {ECO:0000313|Ensembl:ENSAMXP00000013793.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000013793.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000013793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RHPN family.
CC {ECO:0000256|ARBA:ARBA00010369}.
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DR RefSeq; XP_007255703.1; XM_007255641.2.
DR AlphaFoldDB; W5L1T1; -.
DR STRING; 7994.ENSAMXP00000013793; -.
DR Ensembl; ENSAMXT00000013793.2; ENSAMXP00000013793.1; ENSAMXG00000013406.2.
DR GeneID; 103039738; -.
DR KEGG; amex:103039738; -.
DR CTD; 114822; -.
DR eggNOG; KOG2220; Eukaryota.
DR GeneTree; ENSGT00940000153837; -.
DR HOGENOM; CLU_006514_1_0_1; -.
DR InParanoid; W5L1T1; -.
DR OMA; PPVHDYM; -.
DR OrthoDB; 24567at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013406; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11633; HR1_Rhophilin-1; 1.
DR CDD; cd00136; PDZ; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.280; alix/aip1 like domains; 1.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR047138; RHPN1_2.
DR PANTHER; PTHR23031; RHOPHILIN; 1.
DR PANTHER; PTHR23031:SF6; RHOPHILIN-1; 1.
DR Pfam; PF03097; BRO1; 1.
DR Pfam; PF02185; HR1; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM01041; BRO1; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51180; BRO1; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51860; REM_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 28..102
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 113..502
FT /note="BRO1"
FT /evidence="ECO:0000259|PROSITE:PS51180"
FT DOMAIN 515..578
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..106
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 664 AA; 74460 MW; 991D52450B6D8AEF CRC64;
MSDTGSEEEV SVLREEGVSG GSVRKGCDPL VLTQRSKLQQ RRAKLNQQIN RELRLRTGAE
NLYRATTNQK VKETVSLELS FVNSNLQLLK EELEELNSSM EVYQTESEKV NVPMIPLGLK
ETKEIDMTIP LQDFISEHYG EDASLYMSEV KEFMDLRQAM RTPSRNDAGL ELLMEYYNQL
YFLDQRFFAP HRTLGVHFHW YDSLTGVPSC QRALAFEKGS VLFNIGALYT QIGARQDRST
LPGIQNAIDA FQRAAGAFLY LQENFSHAPS LDMSSPALSM LVRLMVAQVQ ECICERVTLT
MEENDLMSNL QAAQESARVS DVYSLVLQAM SVPLLKDYVP FSWLSVVQVK TQHFRALAHY
YTAAALCDCS DMIDKVNDCG SAVKALKLVH TRPPDTLCLQ EPEDRLRLGK GHLRKAIIRH
EEALRLHGVC KMLRKMDILQ EVLSYAHTRS LEKYSDIDQE DDFCEIAEAP EIQSHTYQKP
DIKTPDFSSV RVTDIFHRLG PLSLFCARNR WVGRRLCLVR GEAGLGLTLR GDSPVLVAGV
LPEGCAAEAG LHEGDYIVAV NGSDCRWAEH AEVVHVLKGC SERGVELDVI TLLTNEVEKR
AASLSPSSDR ETVTQQRQGG DSDRGSTSLL NWSWRSGGGG RVTKRLGSTF SLPFGSLRES
ESMY
//
