ID W5L2K7_ASTMX Unreviewed; 493 AA.
AC W5L2K7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Si:dkeyp-47f9.4 {ECO:0000313|Ensembl:ENSAMXP00000014069.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000014069.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000014069.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5L2K7; -.
DR STRING; 7994.ENSAMXP00000014069; -.
DR Ensembl; ENSAMXT00000014069.2; ENSAMXP00000014069.2; ENSAMXG00000013662.2.
DR eggNOG; KOG0241; Eukaryota.
DR eggNOG; KOG4568; Eukaryota.
DR GeneTree; ENSGT00940000157706; -.
DR HOGENOM; CLU_023687_1_0_1; -.
DR InParanoid; W5L2K7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013662; Expressed in camera-type eye and 10 other cell types or tissues.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR PANTHER; PTHR18916:SF32; CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 4; 1.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..493
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017307729"
FT REPEAT 210..242
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 330..372
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 376..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 53489 MW; F259F835E6A0C8CA CRC64;
MILSFFLSLC VCVRVCVRSG VEGEMTKEEV LRESSEGDAV LERYSVVSHT AARPVIHQVA
SAPMPTDSDF SFFDPTDPQC REVLLDPQTS VPELFAVLRQ WVPQVQKNIS RIGNEILKRG
CGVNDRDGLT DMSLLHYCCK AGAPGIGDAE NAASFARKLL SLGAEPSLRS RWTNMSALHY
AAYFDVPPLI RVVLQASQPG EVDATCSDFD FGTALHIAAS NICTAAVRCL LELGANPAFR
NDKGQCPADV VPEPLDMPLE MADAAAQAKE LRTLLREALP RPSAPLPVLP GRPLSLLTEK
ARSQLSSMGI CLGDKVIIAG QKVGTLRFCG STEFAGGLWA GVELQQPEGK NDGSVAGVQY
FTCPVKHGIF APLSKITKFS ERRRPSPRQP AAPVRPPRHI DLARVKSKVD TGALSRSCST
SSSSLDSRQA PGRRPPLPLP RQRRPLRPRQ ERTTPSARST PVPAYRSLSS TPQPGRVTLF
LVSPLQLCVI QNR
//
