ID W5L4U2_ASTMX Unreviewed; 1783 AA.
AC W5L4U2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=B-TFIID TATA-box binding protein associated factor 1 {ECO:0000313|Ensembl:ENSAMXP00000014854.2};
GN Name=BTAF1 {ECO:0000313|Ensembl:ENSAMXP00000014854.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000014854.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000014854.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000014854.2; ENSAMXP00000014854.2; ENSAMXG00000014437.2.
DR eggNOG; KOG0392; Eukaryota.
DR GeneTree; ENSGT00940000157500; -.
DR HOGENOM; CLU_000315_1_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014437; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR CDD; cd17999; DEXHc_Mot1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR044972; Mot1.
DR InterPro; IPR044078; Mot1_ATP-bd.
DR InterPro; IPR022707; Mot1_central_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR36498; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR PANTHER; PTHR36498:SF1; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR Pfam; PF12054; DUF3535; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1234..1409
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1592..1746
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 75..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1783 AA; 198413 MW; 9D5E664B9EA75ED2 CRC64;
MAVSRLERLF ILLDTGTTPV TRKAAAQQLG DVVKLHPHEL NNLLAKVLLY LRSPNWDTRI
AAGQAVEAIV KNIPEWNPSP KPKEESCAED MSPEDNSSDR LSFYRFDISR LLKHGASLLG
SAGAEFELQD DKSGEVDPKE RLARQRKLLQ KKLGLDMGAA IGMDTEELFN DEDLDYTCAS
NANRAQVGRV AACHSSRNHT AAELIDSEFR PGMSNRQRNK AKRMAKLVAK QRSRDLDPNE
KSNDSFEGEP EEKRRKTTNV VIDQPATENK VLIDNVPDNS SLLEETQEWP LESFCEELCN
DLFNPSWEIR HGAGTGLREV LKCHGTGGGK LVGSTSEQLA QQHQEWMEDL VIRLLCVFAL
DRFGDFVSDE VVAPVRETCA QTLGVALRHM TDSGVAMTVD VLLKLLTEDQ WEVRHGGLLG
IKYALAVRQN LISELLPRVL PAITEGLQDL DDDVRAVAAA ALIPVVDGLV HLQPAKVPFI
VNTLWDALLE LDDLTASTNS IMTLLSSLLT YPQVLQCSMQ QSLTVLVPRV WPFLRHTIAS
VRRAALETLF TLLSKADQSG AVWLNPILQD MLRHIFQSCI LESNQEILDL IQKEKASGKP
RQGGTQVKEA VQEYIGGADT ITEDQGTRDY VVTRARLMAA KLLGALCRCI CDPQLNSSTQ
EIRPAESLAQ LLLFHLNSKS ALQRIAVAMV LCEWAFVQNE CEIVSSVVQP RLLAILSEQL
YYDEIAIPFT RMQNECKQLI SLLADAHIDV RERINSSVFT IDQANELVTT IFSDATASLN
LKSRQFQPLD SKRQQTCSTV VETNTEWQQL HLRVHTFTAC AVVSLAALPE KLNPVVRPLM
EAVKKEENTL VQGYAASKIA QLLQLCAGRT PCPNAKIVKN LCSSVCVDPM LTPNAGCPVQ
PPAPPTQEGG KASMSEKDGM HHMVNKTKGI ITLYRHQRAA FAITSKRGPT PKLSKPPPND
LSAGSSLSVD SDESKKPILI QRRGAEFSLM TVAKHFGSEL TKALPYLWES MIGPLKAVAE
TLDSRQLLEK GDSVAQELVC SLQVLEVTAG AMAQVLIPLL FEQLPLLCTC LHHPYTAVRH
MAARCVGVLS KIATMETMNV FLERVLPWLG AIDDCTKQEG AIEAMACVME QLDVDIVPYI
VLLVVPVLGR MSDPSDSVRF MATQCFATLI RLLPLEAGIP DPPSMSDDLI RQKARERHFL
EQLLDGRKLE NYKIPVPIKA ELRKYQQDGV NWLAFLNKYK LHGILCDDMG LGKTLQSICI
LAGDHYLRAQ EYTKTKAADS CPLPSIVVCP PTLTGHWVDE VGKFCTKEYL NPLHYTGPPT
ERARLQHQVK KHNLVVASYD VVRNDIDFFR NIKFNYCILD EGHVIKNGKT KLSKAIKQLA
ANYRVILSGT PIQNNVLELW SLFDFLMPGF LGTERQFAAR YGKPILASRD AKSSSREQEA
GVLAMEALHR QVLPFLLRRM KEDVLQDLPP KIIQDYYCNL SPLQVQLYED FAKSRAKVSV
DDVISTAVKE EEEEKPKLKA TGHVFQALQY LRKLCNHPAL VLTPQHPEHK RISEQLSSQH
SSLRDIQHAP KLSALKQLLL DCGLGSAGSS DGGTEAVVAQ HRVLIFCQLK SMLDIVEQDL
LKPQLPSVTY LRLDGSVPAG LRHSIVSRFN NDPSIDVLLL TTHVGGLGLN LTGADTVVFV
EHDWNPMRDL QAMDRAHRIG QKRVVNVYRL ITRGTLEEKI MGLQKFKMSI ANTVISQDNS
SLQSMGTDQL LNLFTLDKVC AHITLILTRL YCICKDNIFK RPS
//
