ID W5L581_ASTMX Unreviewed; 737 AA.
AC W5L581;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSAMXP00000014993.2};
GN Name=LRGUK {ECO:0000313|Ensembl:ENSAMXP00000014993.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000014993.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000014993.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5L581; -.
DR Ensembl; ENSAMXT00000014993.2; ENSAMXP00000014993.2; ENSAMXG00000014569.2.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; KOG0707; Eukaryota.
DR GeneTree; ENSGT00940000157992; -.
DR HOGENOM; CLU_019293_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014569; Expressed in testis and 7 other cell types or tissues.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 312..495
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 505..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 82110 MW; 3BB9BB86E29DB8E1 CRC64;
MEDAELTREV VEKHLSTLGR SGQSFAYQFL TVPRQNLKNV SILSEYTHLR KLELPYNKIK
DLSCVSHMPN LIILDASHNE LSTFFGFQPP KYLKEVNFSH NQISEMKDLS AYFSLNKLIL
DYNSITEIKG VEKCSSLIHF SIAHNKISRI SGLNNLPLKH LCLRGNLIKK IENLHTLRAL
QFLDISSNRI HSLSGLQNLP LLGSINFESN MISEIKEVSY LHDILLLREL NLKRNPVQEQ
PDYRMMVIFL LNRLTELDEL AVTAVDKVTA VNKYDPPLEV VAARDHMTHM VYQHLQPQVI
FDSTLPSLDA PYPLLILTGP QACGKRELAH KLCQDFCDYF AYGACHTTRG PYFGEEDGSD
YHFVLEEEFQ NMIRMGRFVQ TMQYGGHWYG LSREAIESAA REGLACCVHM EIEGVYSLKN
SYFEPRYILL IPTSTEEYIS RMKARGLYSN AQIDTAVSRI DLYVRVNREQ PGFFDSVIPS
DNREEAYMRL KQIVEDFLGL HEQGAEGDRT RVIPDSSSQG ENGEALASQK VEVNPADTDS
MNYWNKVQAR LTPQKTSAEL ASIHRKKQML REALMGKSPG VYPQLFKRHA HTAPSLLGPP
SQPGASSSLM PSFGRPLSDR IEDSSSEESR ASSGLSVHSS AGALSAGSPA EGLDAGSGPK
VEPLDISVLG QNLESLKDPL ESGLTPDAPR SVPEQASPTP LTTSPGRPGS NAKPILPPIP
SGRKGDTPSS RQSLTGQ
//
