ID W5L5J8_ASTMX Unreviewed; 602 AA.
AC W5L5J8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=GATA zinc finger domain containing 2B {ECO:0000313|Ensembl:ENSAMXP00000015110.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015110.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015110.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; W5L5J8; -.
DR STRING; 7994.ENSAMXP00000015110; -.
DR Ensembl; ENSAMXT00000015110.2; ENSAMXP00000015110.2; ENSAMXG00000014687.2.
DR eggNOG; KOG3740; Eukaryota.
DR GeneTree; ENSGT00390000004097; -.
DR HOGENOM; CLU_014315_2_0_1; -.
DR InParanoid; W5L5J8; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014687; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.250.1650; -; 1.
DR InterPro; IPR040386; P66.
DR InterPro; IPR032346; P66_CC.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR13455:SF4; TRANSCRIPTIONAL REPRESSOR P66-BETA; 1.
DR PANTHER; PTHR13455; TRANSCRIPTIONAL REPRESSOR P66-RELATED; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF16563; P66_CC; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00094};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 422..452
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 95..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 65517 MW; CCBFA8A3334910EB CRC64;
MERMSEEALR LNLLKRGLET ADEREEALAK RLKMEGHEAM ERLKMLALLK RKDLAALEGA
AMAAAMAEGK GPGGSQGLMG ASAYEEKLNG SMRVVSHGGP SKNGKENMMD EPVDMSAKRS
DVDRERRTPS PDVIILSDNE ASSPRSTPHP EERHHRPNLE MFKGKTGEER QQMIKALREE
LRLEEARLVL LKKLRQSQMQ KENVVQKVPV VQNTPSSVQP SPIHSSQGLT KLPVRPGMHT
SEPQNLRAAQ GHTVIRSAAS ASLPPMMMSQ RVIAPNPAQL QGQRVPSKPG MGRSSTGSMG
NAVNYQQVCS QVAASQRSNS STAIYMNLAH IPSTLPSGSS VAAVGSVSSL NDQASSQAAA
KLALRKQLEK TLLEIPPPKP PAPLLHFLPS AANSEFIYMV GLEEVVQSVI DSQGKMRGSL
SRLEPFFCAQ CRTDFTPHWK QEKSGRILCE QCMTSNQKKA LKAEHTNRLK NAFVKALQQE
QEIEQRLQQQ AALSPSAAQT VPSVSKAESM IRHHALRQAP QPQAALQRGL SSSARGVLSN
FAQASQLSVA SGLLGMTRLN IAYLNPGAVG GHKASSLADR QREYLLDMIP PRSISQSITG
QK
//
