ID   W5L5P0_ASTMX            Unreviewed;      1418 AA.
AC   W5L5P0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Nebulin-related anchoring protein {ECO:0000313|Ensembl:ENSAMXP00000015152.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015152.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000015152.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 7994.ENSAMXP00000015152; -.
DR   Ensembl; ENSAMXT00000015152.2; ENSAMXP00000015152.2; ENSAMXG00000014720.2.
DR   eggNOG; KOG1702; Eukaryota.
DR   GeneTree; ENSGT00940000158418; -.
DR   HOGENOM; CLU_003010_1_0_1; -.
DR   InParanoid; W5L5P0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000014720; Expressed in muscle tissue and 8 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0060297; P:regulation of sarcomere organization; IEA:Ensembl.
DR   GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR   CDD; cd09446; LIM_N_RAP; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   InterPro; IPR013998; Nebulin-like.
DR   InterPro; IPR000900; Nebulin_repeat.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR11039; NEBULIN; 1.
DR   PANTHER; PTHR11039:SF39; NEBULIN-RELATED-ANCHORING PROTEIN; 1.
DR   Pfam; PF00412; LIM; 1.
DR   Pfam; PF00880; Nebulin; 18.
DR   PRINTS; PR00510; NEBULIN.
DR   SMART; SM00132; LIM; 1.
DR   SMART; SM00227; NEBU; 35.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR   PROSITE; PS51216; NEBULIN; 22.
PE   4: Predicted;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW   ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT   DOMAIN          4..64
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
SQ   SEQUENCE   1418 AA;  161396 MW;  B357C4C07784469A CRC64;
     MNIQNCARCG FVVYPAEKIN LISQNWHKAC FHCEVCKMVL TANNFVSHQK RPYCQVHNPR
     NNTFTSVYET PVNINAKKQA EAVSEIKYRE EGERFMSTFH YDMRSKELEQ ARKASQMTNQ
     AYQSLGFSEQ QTWYSGSVTS QEIVRMSQAQ KTISDYTEVY EQSKGKGSFP AMLTPGYEVA
     KKANTLASNV EYKKGHEERV SKYTTVTDSP EVLLAKSQGR IASDFVYTED YEQQRGKGSF
     PAHVTPGYQT VKKANEMASK VKYQQKYEQE MKGKASTDAG FCTSLLSVFI GLSSQHAYTE
     EYEQQRGKGS FPAMITPGYQ MAKKANDIAS DLKYKKDLNK MKGSSAYHSL TTDDNLTLKN
     ACKINKLVSE NKYKEKYTSH MKGHYEGTGV DKKTAHAMKV RKLASNVRFH YCYSTAIPTL
     WCAKNYRQHI DKLKYSQVTD TPDIIQARIN AQQLSNVNYK ADYEKTKTQY TIAQDTPQLQ
     KAKANAELIS DIKYKEEWEK NKSKVHDVGA DTLTLKAAKA SRDLASDIKY KELFVKNKDK
     AVGVNVSDSK TLHCLQVGKL NSEIAYKKNS KETQAKYNLT KDMVNLSHAK KAQALASDLD
     YRKKLHEYTI LPDDIKVQQA KKAYNLQSDN QYRSDLVWMK GVGWEAEGCL DVEQAKKAGE
     LLSDKKYRQK VDSVKFTQVA DTPSIQHAKK SQELQSDLTY KAGTEQIIHQ YTVSKDEPLY
     KQAKANAELL SNKSYKSSWE AQREKGFELS MDALSILTAK AKRDLASDVK YKQQYEMTKG
     KMIGVKNVTD DSHLAHSALA TKLQSDRNYK KEYEDTKTKH SASLDMMTIS HAKKAQDLAT
     ETNYRTILHE YTTLPSDMKV AWAKKAYGQQ SDKKYRSDLN WMKGVGWETT GSLDVKQARK
     ASDLASEKKY RQHVSALKFT SVEDTPEMVQ AKLSNKLALD RLYREKGETE KHKYTMTGDL
     PEHVQAKMNA RNISESRYKE SWMKLRDGGY KLRLDAIPFQ AAKSSGEVLS DQKYKEEFLK
     MKGKMIGLKA LQDDINIAHS VHASHLQSDI KYKKDSTKVH SQFHLPMDML EVAHAKKAQA
     LVSDQDYRMT LHNYTTLPDD LNVQAAKRAY SLQSEHHNLL SYRSDLNYLR GAAWIATGAL
     QIEGSKHATQ LISDKKYRQQ PYTFKHTSVT DSPDIVHAKL SNKLTNERLY KEKGENFRHN
     YTITAERPEI TQAKINAANY SDTKYKESWH TLRAQGYKLT MQDIPFQAAK ASTDIASDYQ
     YKHNHVLEKG KHIGARSIMD DSHLLHCMQT AHLQSDKNYR KDAIATSGQF HLGMDLVNLV
     HAKKAQSLAS DQDYKTRLHS YTVLPDDIKV QWAKKAYELQ SQNAYKSDLN FMKGVAWDSV
     GAPQLESAKK AGELISDVKY KSDLNWIKGV GWTPPGLS
//