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Database: UniProt
Entry: W5L5R8_ASTMX
LinkDB: W5L5R8_ASTMX
Original site: W5L5R8_ASTMX 
ID   W5L5R8_ASTMX            Unreviewed;       419 AA.
AC   W5L5R8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=tRNA methyltransferase 10 homolog C {ECO:0000256|ARBA:ARBA00014681};
DE            EC=2.1.1.218 {ECO:0000256|ARBA:ARBA00012794};
DE            EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
DE   AltName: Full=Mitochondrial ribonuclease P protein 1 {ECO:0000256|ARBA:ARBA00030623};
DE   AltName: Full=RNA (guanine-9-)-methyltransferase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029803};
DE   AltName: Full=mRNA methyladenosine-N(1)-methyltransferase {ECO:0000256|ARBA:ARBA00031759};
DE   AltName: Full=tRNA (adenine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00033019};
DE   AltName: Full=tRNA (guanine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00029727};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015180.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000015180.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43148, Rhea:RHEA-COMP:10363, Rhea:RHEA-COMP:10364,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.218;
CC         Evidence={ECO:0000256|ARBA:ARBA00001023};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-
CC         methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:55392, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12415,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74491;
CC         Evidence={ECO:0000256|ARBA:ARBA00033688};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC         Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR   AlphaFoldDB; W5L5R8; -.
DR   SMR; W5L5R8; -.
DR   STRING; 7994.ENSAMXP00000015180; -.
DR   Ensembl; ENSAMXT00000015180.2; ENSAMXP00000015180.2; ENSAMXG00000014749.2.
DR   eggNOG; KOG2967; Eukaryota.
DR   GeneTree; ENSGT00530000063169; -.
DR   HOGENOM; CLU_034384_3_1_1; -.
DR   InParanoid; W5L5R8; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000014749; Expressed in heart and 14 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:GOC.
DR   CDD; cd18102; Trm10_MRRP1; 1.
DR   Gene3D; 3.40.1280.30; -; 1.
DR   InterPro; IPR028564; MT_TRM10-typ.
DR   InterPro; IPR038459; MT_TRM10-typ_sf.
DR   InterPro; IPR025812; Trm10_C_MTase_dom.
DR   InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR   InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR   PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR13563:SF5; TRNA METHYLTRANSFERASE 10 HOMOLOG C; 1.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   PROSITE; PS51675; SAM_MT_TRM10; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          207..400
FT                   /note="SAM-dependent MTase TRM10-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51675"
SQ   SEQUENCE   419 AA;  48517 MW;  E8DBBA159BB1D365 CRC64;
     MTFLRLQVVG VLRRCCGRPS SSAALKCHYS GLPTSSFIST PSSALTSSRA LSTTWILRKD
     VPQPKDEEAR PKLDLDVWKS MMRTVALQED RVKTKDKVEG KLSPLEATRM LVDAWRLAGR
     LVPDSLTDEQ MEALSKLTTK SSKRKFLKHL SIKEGYKKAK MEKKEKKMAE RMERADREGF
     DVDSKADVKL KNTFLMKFWS RSLDTLLFWR SAQAMQYGQP LVFDMSYEQH MSSHDAKNTV
     SQLLQCEGWN RRSVDPFHLH FCNLQPNSVY HQELLKRYGQ ETWERLFITT TSQRHVDIFP
     RENLVYLTAD SPNVLRTFDH NKVYIIGAFV DRSAQSGVSL ANAKRLKLAT ARLPLNEHLQ
     WDCGAKNLTL DQMIQILITI KETGSWEKAL EFVPIRKHGG FYEQKTENSV FIRFHQWYE
//
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