ID W5L5U5_ASTMX Unreviewed; 677 AA.
AC W5L5U5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=GRAM domain containing 1C {ECO:0000313|Ensembl:ENSAMXP00000015207.2};
GN Name=GRAMD1C {ECO:0000313|Ensembl:ENSAMXP00000015207.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015207.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015207.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR AlphaFoldDB; W5L5U5; -.
DR STRING; 7994.ENSAMXP00000015207; -.
DR Ensembl; ENSAMXT00000015207.2; ENSAMXP00000015207.2; ENSAMXG00000014778.2.
DR eggNOG; KOG1032; Eukaryota.
DR GeneTree; ENSGT00940000158013; -.
DR HOGENOM; CLU_015189_1_0_1; -.
DR InParanoid; W5L5U5; -.
DR OrthoDB; 45896at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014778; Expressed in intestine and 11 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF1; PROTEIN ASTER-C; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 572..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 342..513
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 78319 MW; D7602B9E8C6111D4 CRC64;
MTPVSKSVAG SDVSEESSQS GEIRLNSEEQ ETEESMEKIA LLWTKDSFQD SDITVQCIGS
PQSPTSYKQR SEEFKRTFKE LADLERLIVD YTCALQRDIL LQGRIYLTEN WLCFYSNVFW
GTKIMVNMRD IASMSREKIA RLIPNAIQVY TNSEKLFFTS FSAREKSYQT IFRLWQNLLL
DKQLTRQELW QMVKQHYGND LGLSYEEMES LQMTADTSAY TQTSLNMKAD DHTSRMERPS
SLRLPQNEQS SYEASTPLGD DTQSSVGLQS TLSANGEDTR STASRQRSPD LSLERFSNER
MSKRSSHSLD LNANEDRLSE NSLSDSMEEG AVERDCVSQA SQGRLYVNRA FRISAEKMFE
LLFTDSYFSR RFMNARKITG ANCTSWQRDA SGSMKRTLNY TITISNPLVG KYSTATENQT
LYKESREGHY YLVDTEVYTH DVPYHDYFYT MNRYCIIRNS KRKCRLRIYT DVKYKKQPWG
FVKSFITKNS WSGLEDYFRH LESELLEEEA ELTQGSGDAG KGGLRRRRRT YSRTLQEHMR
PGKQYGADTE QHRDGNLGAA DMKSTQKWNI TFIIAGMSLI LLFLTVLNLG LFFKLWAMED
VAHRMYLSTK QRMRERAEAN LSPELGPRQT LFHRSPEETR LLRAVLQDSI NLLEQLRSSL
VVLQQNFQGH NKTSNQV
//
